| PÁVKOVÁ GOLDBERGOVÁ, Monika, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Jiří PAŘENICA, Lenka ŠIŠKOVÁ, Ladislav GROCH, Jan MÁCHAL a Anna VAŠKŮ. Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor? Physiological Research. Praha: Institute of Physiology, Academy of Sci., 2011, roč. 60, č. 1, s. 55-64. ISSN 0862-8408. |
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@article{921485,
author = {Pávková Goldbergová, Monika and Špinarová, Lenka and Špinar, Jindřich and Pařenica, Jiří and Šišková, Lenka and Groch, Ladislav and Máchal, Jan and Vašků, Anna},
article_location = {Praha},
article_number = {1},
keywords = {RAAS; heart failure; AGT},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?},
volume = {60},
year = {2011}
}
TY - JOUR
ID - 921485
AU - Pávková Goldbergová, Monika - Špinarová, Lenka - Špinar, Jindřich - Pařenica, Jiří - Šišková, Lenka - Groch, Ladislav - Máchal, Jan - Vašků, Anna
PY - 2011
TI - Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?
JF - Physiological Research
VL - 60
IS - 1
SP - 55-64
EP - 55-64
PB - Institute of Physiology, Academy of Sci.
SN - 08628408
KW - RAAS
KW - heart failure
KW - AGT
N2 - Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was observed also in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF - P < 0.001; and AA vs. DCM - P<0.001) we found the same trend. These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes.
ER -
PÁVKOVÁ GOLDBERGOVÁ, Monika, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Jiří PAŘENICA, Lenka ŠIŠKOVÁ, Ladislav GROCH, Jan MÁCHAL a Anna VAŠKŮ. Difference in angiotensinogen haplotype frequences between chronic heart failure and advanced atherosclerosis patients - new prognostic factor? \textit{Physiological Research}. Praha: Institute of Physiology, Academy of Sci., 2011, roč.~60, č.~1, s.~55-64. ISSN~0862-8408.
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