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@article{921695,
author = {Skoloudik, D. and Fadrná, Táňa and Roubec, Martin and Bar, Michal and Zapletal, Ondřej and Blatný, Jan and Langová, Kateřina and Bardon, Petr and Sanák, Daniel and Kanovský, Petr},
article_location = {USA},
article_number = {7},
doi = {http://dx.doi.org/10.1016/j.ultrasmedbio.2010.04.010},
keywords = {Ultrasound monitoring; Sono-thrombolysis; Stroke; Hemocoagulation; Fibrinolytic system; Transcranial Doppler},
language = {cze},
issn = {0301-5629},
journal = {Ultrasound In Medicine And Biology},
title = {Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe.},
volume = {36},
year = {2010}
}
TY - JOUR
ID - 921695
AU - Skoloudik, D. - Fadrná, Táňa - Roubec, Martin - Bar, Michal - Zapletal, Ondřej - Blatný, Jan - Langová, Kateřina - Bardon, Petr - Sanák, Daniel - Kanovský, Petr
PY - 2010
TI - Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe.
JF - Ultrasound In Medicine And Biology
VL - 36
IS - 7
SP - 1052-1059
EP - 1052-1059
PB - ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH
SN - 03015629
KW - Ultrasound monitoring
KW - Sono-thrombolysis
KW - Stroke
KW - Hemocoagulation
KW - Fibrinolytic system
KW - Transcranial Doppler
N2 - The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 +/- 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 +/- 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and alpha-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p < 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively). The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode.
ER -
SKOLOUDIK, D., Táňa FADRNÁ, Martin ROUBEC, Michal BAR, Ondřej ZAPLETAL, Jan BLATNÝ, Kateřina LANGOVÁ a Petr BARDON. Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe. Herzig Roman. \textit{Ultrasound In Medicine And Biology}. USA: ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, 2010, roč.~36, č.~7, s.~1052-1059, 7 s. ISSN~0301-5629. Dostupné z: https://dx.doi.org/10.1016/j.ultrasmedbio.2010.04.010.
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