KŘEN, Leoš, Ondřej SLABÝ, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL, Tomáš SVOBODA, Pavel FADRUS, Radek LAKOMÝ, Petr VAŇHARA, Zdenka KŘENOVÁ, Jaroslav ŠTĚRBA, Martin SMRČKA and Jaroslav MICHÁLEK. Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance? Neuropathology. 2011, vol. 31, No 2, p. 129-134. ISSN 0919-6544. Available from: https://dx.doi.org/10.1111/j.1440-1789.2010.01149.x.
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Basic information
Original name Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?
Authors KŘEN, Leoš (203 Czech Republic, guarantor, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Katarína MÚČKOVÁ (703 Slovakia, belonging to the institution), Eva LŽIČAŘOVÁ (203 Czech Republic, belonging to the institution), Marek SOVA (203 Czech Republic), Václav VYBÍHAL (203 Czech Republic, belonging to the institution), Tomáš SVOBODA (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution), Radek LAKOMÝ (203 Czech Republic, belonging to the institution), Petr VAŇHARA (203 Czech Republic, belonging to the institution), Zdenka KŘENOVÁ (203 Czech Republic, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution) and Jaroslav MICHÁLEK (203 Czech Republic, belonging to the institution).
Edition Neuropathology, 2011, 0919-6544.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.022
RIV identification code RIV/00216224:14110/11:00051771
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1111/j.1440-1789.2010.01149.x
UT WoS 000288547400004
Keywords in English glioblastoma; HLA-E; HLA-G; survival
Tags International impact
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 1/8/2013 10:52.
Abstract
The role of nonclassical human leukocyte antigens G and E (HLA-G and HLA-E) was originally thought to be restricted to the protection of the fetus from a maternal allorecognition. Now it is known that HLA-G and HLA-E exert multiple immunoregulatory functions. A prognostic significance of the expression of HLA-G and HLA-E by neoplastic cells in glioblastoma is not well characterized. In this study, we evaluated the expression of HLA-G and HLA-E by neoplastic cells in 39 cases of glioblastoma. We found the production of HLA-G and HLA in a majority of cases. There was an unexpected positive correlation between the expression of HLA-E and length of survival. We speculate that the expression of this molecule by neoplastic cells may represent a coincidental selective pro-host advantage related to better response to subsequent therapeutic modalities. Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study.
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