Expression of immune-modulatory molecules HLA-G and HLA-E by
tumor cells in glioblastomas: An unexpected prognostic
significance?

J 2011

Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?

KŘEN, Leoš, Ondřej SLABÝ, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA et. al.

Základní údaje

Originální název

Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?

Autoři

KŘEN, Leoš (203 Česká republika, garant, domácí), Ondřej SLABÝ (203 Česká republika, domácí), Katarína MÚČKOVÁ (703 Slovensko, domácí), Eva LŽIČAŘOVÁ (203 Česká republika, domácí), Marek SOVA (203 Česká republika), Václav VYBÍHAL (203 Česká republika, domácí), Tomáš SVOBODA (203 Česká republika, domácí), Pavel FADRUS (203 Česká republika, domácí), Radek LAKOMÝ (203 Česká republika, domácí), Petr VAŇHARA (203 Česká republika, domácí), Zdenka KŘENOVÁ (203 Česká republika, domácí), Jaroslav ŠTĚRBA (203 Česká republika, domácí), Martin SMRČKA (203 Česká republika, domácí) a Jaroslav MICHÁLEK (203 Česká republika, domácí)

Vydání

Neuropathology, 2011, 0919-6544

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.022

Kód RIV

RIV/00216224:14110/11:00051771

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/j.1440-1789.2010.01149.x

UT WoS

000288547400004

Klíčová slova anglicky

glioblastoma; HLA-E; HLA-G; survival

Příznaky

Mezinárodní význam

Změněno: 1. 8. 2013 10:52, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

The role of nonclassical human leukocyte antigens G and E (HLA-G and HLA-E) was originally thought to be restricted to the protection of the fetus from a maternal allorecognition. Now it is known that HLA-G and HLA-E exert multiple immunoregulatory functions. A prognostic significance of the expression of HLA-G and HLA-E by neoplastic cells in glioblastoma is not well characterized. In this study, we evaluated the expression of HLA-G and HLA-E by neoplastic cells in 39 cases of glioblastoma. We found the production of HLA-G and HLA in a majority of cases. There was an unexpected positive correlation between the expression of HLA-E and length of survival. We speculate that the expression of this molecule by neoplastic cells may represent a coincidental selective pro-host advantage related to better response to subsequent therapeutic modalities. Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study.

Citovat

KŘEN, Leoš, Ondřej SLABÝ, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL, Tomáš SVOBODA, Pavel FADRUS, Radek LAKOMÝ, Petr VAŇHARA, Zdenka KŘENOVÁ, Jaroslav ŠTĚRBA, Martin SMRČKA a Jaroslav MICHÁLEK. Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance? Neuropathology. 2011, roč. 31, č. 2, s. 129-134. ISSN 0919-6544. Dostupné z: https://dx.doi.org/10.1111/j.1440-1789.2010.01149.x.

@article{921912,
   author = {Křen, Leoš and Slabý, Ondřej and Múčková, Katarína and Lžičařová, Eva and Sova, Marek and Vybíhal, Václav and Svoboda, Tomáš and Fadrus, Pavel and Lakomý, Radek and Vaňhara, Petr and Křenová, Zdenka and Štěrba, Jaroslav and Smrčka, Martin and Michálek, Jaroslav},
   article_number = {2},
   doi = {http://dx.doi.org/10.1111/j.1440-1789.2010.01149.x},
   keywords = {glioblastoma; HLA-E; HLA-G; survival},
   language = {eng},
   issn = {0919-6544},
   journal = {Neuropathology},
   title = {Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?},
   volume = {31},
   year = {2011}
}

TY  - JOUR
ID  - 921912
AU  - Křen, Leoš - Slabý, Ondřej - Múčková, Katarína - Lžičařová, Eva - Sova, Marek - Vybíhal, Václav - Svoboda, Tomáš - Fadrus, Pavel - Lakomý, Radek - Vaňhara, Petr - Křenová, Zdenka - Štěrba, Jaroslav - Smrčka, Martin - Michálek, Jaroslav
PY  - 2011
TI  - Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?
JF  - Neuropathology
VL  - 31
IS  - 2
SP  - 129-134
EP  - 129-134
SN  - 09196544
KW  - glioblastoma
KW  - HLA-E
KW  - HLA-G
KW  - survival
N2  - The role of nonclassical human leukocyte antigens G and E (HLA-G and HLA-E) was originally thought to be restricted to the protection of the fetus from a maternal allorecognition. Now it is known that HLA-G and HLA-E exert multiple immunoregulatory functions. A prognostic significance of the expression of HLA-G and HLA-E by neoplastic cells in glioblastoma is not well characterized. In this study, we evaluated the expression of HLA-G and HLA-E by neoplastic cells in 39 cases of glioblastoma. We found the production of HLA-G and HLA in a majority of cases. There was an unexpected positive correlation between the expression of HLA-E and length of survival. We speculate that the expression of this molecule by neoplastic cells may represent a coincidental selective pro-host advantage related to better response to subsequent therapeutic modalities. Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study.
ER  -

KŘEN, Leoš, Ondřej SLABÝ, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL, Tomáš SVOBODA, Pavel FADRUS, Radek LAKOMÝ, Petr VAŇHARA, Zdenka KŘENOVÁ, Jaroslav ŠTĚRBA, Martin SMRČKA a Jaroslav MICHÁLEK. Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance? \textit{Neuropathology}. 2011, roč.~31, č.~2, s.~129-134. ISSN~0919-6544. Dostupné z: https://dx.doi.org/10.1111/j.1440-1789.2010.01149.x.

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