| HORKÝ, Ondřej, Jiří MAYER, Lenka KABLÁSKOVÁ, Filip RÁZGA, Marta KREJČÍ, Jarmila KISSOVÁ, Marek BORSKÝ, Ivana JEŽÍŠKOVÁ a Dana DVOŘÁKOVÁ. Increasing hematopoietic microchimerism is a reliable indicator of incipient AML relapse. International Journal of Laboratory Hematology. 2010, roč. 33, č. 1, 10 s. ISSN 1751-5521. |
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@article{922804,
author = {Horký, Ondřej and Mayer, Jiří and Kablásková, Lenka and Rázga, Filip and Krejčí, Marta and Kissová, Jarmila and Borský, Marek and Ježíšková, Ivana and Dvořáková, Dana},
article_number = {1},
keywords = {microchimerism; chimerism; real-time PCR; relapse; acute myeloid leukemia},
language = {eng},
issn = {1751-5521},
journal = {International Journal of Laboratory Hematology},
title = {Increasing hematopoietic microchimerism is a reliable indicator of incipient AML relapse},
volume = {33},
year = {2010}
}
TY - JOUR
ID - 922804
AU - Horký, Ondřej - Mayer, Jiří - Kablásková, Lenka - Rázga, Filip - Krejčí, Marta - Kissová, Jarmila - Borský, Marek - Ježíšková, Ivana - Dvořáková, Dana
PY - 2010
TI - Increasing hematopoietic microchimerism is a reliable indicator of incipient AML relapse
JF - International Journal of Laboratory Hematology
VL - 33
IS - 1
SN - 17515521
KW - microchimerism
KW - chimerism
KW - real-time PCR
KW - relapse
KW - acute myeloid leukemia
N2 - Using real-time PCR (RQ-PCR), we compare peripheral blood samples obtained from patients with acute myeloid leukemia (AML) before hematological relapse and those taken during complete remission. By comparison of these two groups, we describe microchimerism dynamics clearly connected with imminent AML relapse. Mere reappearance of autologous hematopoiesis within patients with complete donor chimerism is alarming, and another sample with further increase confirms ongoing relapse. In case of patients with continuous microchimerism, another two consecutive samples with increasing trend are required. RQ-PCR predicted a significantly higher number of hematological relapses (87% vs. 39%) with a median anticipation period of 33 days, 26 days earlier than conventional PCR (P = 0.0002). Moreover, the outcome of microchimerism dynamics was in complete agreement with monitoring of minimal residual disease when analyzed from the same cell compartment.
ER -
HORKÝ, Ondřej, Jiří MAYER, Lenka KABLÁSKOVÁ, Filip RÁZGA, Marta KREJČÍ, Jarmila KISSOVÁ, Marek BORSKÝ, Ivana JEŽÍŠKOVÁ a Dana DVOŘÁKOVÁ. Increasing hematopoietic microchimerism is a reliable indicator of incipient AML relapse. \textit{International Journal of Laboratory Hematology}. 2010, roč.~33, č.~1, 10 s. ISSN~1751-5521.
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