| MOHELNÍKOVÁ-DUCHOŇOVÁ, B., O. HAVRÁNEK, I. HLAVATA, Lenka FORETOVÁ, Zdeněk KLEIBL, Petr POHLREICH a Pavel SOUCEK. CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer. Cancer epidemiology. Oxford: Elsevier, 2010, roč. 34, č. 5, s. 656-658. ISSN 1877-7821. Dostupné z: https://dx.doi.org/10.1016/j.canep.2010.06.008. |
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@article{923437,
author = {MohelníkováandDuchoňová, B. and Havránek, O. and Hlavata, I. and Foretová, Lenka and Kleibl, Zdeněk and Pohlreich, Petr and Soucek, Pavel},
article_location = {Oxford},
article_number = {5},
doi = {http://dx.doi.org/10.1016/j.canep.2010.06.008},
keywords = {Checkpoint kinase 2; Alterations; Deletion; Pancreatic cancer; Risk},
language = {eng},
issn = {1877-7821},
journal = {Cancer epidemiology},
title = {CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer},
volume = {34},
year = {2010}
}
TY - JOUR
ID - 923437
AU - Mohelníková-Duchoňová, B. - Havránek, O. - Hlavata, I. - Foretová, Lenka - Kleibl, Zdeněk - Pohlreich, Petr - Soucek, Pavel
PY - 2010
TI - CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer
JF - Cancer epidemiology
VL - 34
IS - 5
SP - 656-658
EP - 656-658
PB - Elsevier
SN - 18777821
KW - Checkpoint kinase 2
KW - Alterations
KW - Deletion
KW - Pancreatic cancer
KW - Risk
N2 - Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR = 5.14; 95% Cl = 0.94-28.23) but the observed association was non-significant (p = 0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395 bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population.
ER -
MOHELNÍKOVÁ-DUCHOŇOVÁ, B., O. HAVRÁNEK, I. HLAVATA, Lenka FORETOVÁ, Zdeněk KLEIBL, Petr POHLREICH a Pavel SOUCEK. CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer. \textit{Cancer epidemiology}. Oxford: Elsevier, 2010, roč.~34, č.~5, s.~656-658. ISSN~1877-7821. Dostupné z: https://dx.doi.org/10.1016/j.canep.2010.06.008.
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