| TRUONG T, T., W. SAUTER, J. MCKAY, H. HOSGOOD, C. GALLAGHER, Ch. AMOS, M. SPITZ, J. MUSCAT, P. LAZARUS, T. ILLIG, H. WICHMANN, H. BICKEBOELLER, A. RISCH, H. DIENEMANN, Zuo-Feng ZHANG, B. NAEIM, P. YANG, S. ZIENOLDDINY, A. HAUGEN, L. LE MARCHAND, Yun-Chul HONG, J. KIM, E. DUELL, A. ANDREW, Ch. KIYOHARA, H. SHEN, K. MATSUO, T. SUZUKI, A. SEOW, D. NG, Q. LAN, D. ZARIDZE, N. SZESZENIA-DABROWSKA, J. LISSOWSKA, P. RUDNAI, E. FABIANOVA, V. CONSTANTINESCU, V. BENCKO, Lenka FORETOVÁ, V. JANOUT, N. CAPORASO, D. ALBANES, M. THUN, M. LANDI, J. TRUBICKA, M. LENER, J. LUBINSKI, Y. WANG, A. CHABRIER, P. BOFFETTA, P. BRENNAN and R. HUNG. International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. Carcinogenesis. Oxford: Oxford University Press, 2010, vol. 31, No 4, p. 625-633. ISSN 0143-3334. Available from: https://dx.doi.org/10.1093/carcin/bgq001. |
Other formats:
BibTeX
LaTeX
RIS
@article{923446,
author = {Truong T, T. and Sauter, W. and McKay, J. and Hosgood, H. and Gallagher, C. and Amos, Ch. and Spitz, M. and Muscat, J. and Lazarus, P. and Illig, T. and Wichmann, H. and Bickeboeller, H. and Risch, A. and Dienemann, H. and Zhang, ZuoandFeng and Naeim, B. and Yang, P. and Zienolddiny, S. and Haugen, A. and Le Marchand, L. and Hong, YunandChul and Kim, J. and Duell, E. and Andrew, A. and Kiyohara, Ch. and Shen, H. and Matsuo, K. and Suzuki, T. and Seow, A. and Ng, D. and Lan, Q. and Zaridze, D. and SzeszeniaandDabrowska, N. and Lissowska, J. and Rudnai, P. and Fabianova, E. and Constantinescu, V. and Bencko, V. and Foretová, Lenka and Janout, V. and Caporaso, N. and Albanes, D. and Thun, M. and Landi, M. and Trubicka, J. and Lener, M. and Lubinski, J. and Wang, Y. and Chabrier, A. and Boffetta, P. and Brennan, P. and Hung, R.},
article_location = {Oxford},
article_number = {4},
doi = {http://dx.doi.org/10.1093/carcin/bgq001},
keywords = {METHYLENE-TETRAHYDROFOLATE REDUCTASE; GENE POLYMORPHISMS; METHYLENETETRAHYDROFOLATE REDUCTASE; CHINESE POPULATION; SEQUENCE VARIANTS; INCREASED RISK; CENTRAL-EUROPE; DNA-REPAIR; XUAN-WEI; CELL},
language = {eng},
issn = {0143-3334},
journal = {Carcinogenesis},
title = {International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.},
volume = {31},
year = {2010}
}
TY - JOUR
ID - 923446
AU - Truong T, T. - Sauter, W. - McKay, J. - Hosgood, H. - Gallagher, C. - Amos, Ch. - Spitz, M. - Muscat, J. - Lazarus, P. - Illig, T. - Wichmann, H. - Bickeboeller, H. - Risch, A. - Dienemann, H. - Zhang, Zuo-Feng - Naeim, B. - Yang, P. - Zienolddiny, S. - Haugen, A. - Le Marchand, L. - Hong, Yun-Chul - Kim, J. - Duell, E. - Andrew, A. - Kiyohara, Ch. - Shen, H. - Matsuo, K. - Suzuki, T. - Seow, A. - Ng, D. - Lan, Q. - Zaridze, D. - Szeszenia-Dabrowska, N. - Lissowska, J. - Rudnai, P. - Fabianova, E. - Constantinescu, V. - Bencko, V. - Foretová, Lenka - Janout, V. - Caporaso, N. - Albanes, D. - Thun, M. - Landi, M. - Trubicka, J. - Lener, M. - Lubinski, J. - Wang, Y. - Chabrier, A. - Boffetta, P. - Brennan, P. - Hung, R.
PY - 2010
TI - International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.
JF - Carcinogenesis
VL - 31
IS - 4
SP - 625-633
EP - 625-633
PB - Oxford University Press
SN - 01433334
KW - METHYLENE-TETRAHYDROFOLATE REDUCTASE
KW - GENE POLYMORPHISMS
KW - METHYLENETETRAHYDROFOLATE REDUCTASE
KW - CHINESE POPULATION
KW - SEQUENCE VARIANTS
KW - INCREASED RISK
KW - CENTRAL-EUROPE
KW - DNA-REPAIR
KW - XUAN-WEI
KW - CELL
N2 - Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancer-related pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3). Methods. Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk. Results. Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 x 10(-4)). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 x 10(-4)]. Conclusion. This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.
ER -
TRUONG T, T., W. SAUTER, J. MCKAY, H. HOSGOOD, C. GALLAGHER, Ch. AMOS, M. SPITZ, J. MUSCAT, P. LAZARUS, T. ILLIG, H. WICHMANN, H. BICKEBOELLER, A. RISCH, H. DIENEMANN, Zuo-Feng ZHANG, B. NAEIM, P. YANG, S. ZIENOLDDINY, A. HAUGEN, L. LE MARCHAND, Yun-Chul HONG, J. KIM, E. DUELL, A. ANDREW, Ch. KIYOHARA, H. SHEN, K. MATSUO, T. SUZUKI, A. SEOW, D. NG, Q. LAN, D. ZARIDZE, N. SZESZENIA-DABROWSKA, J. LISSOWSKA, P. RUDNAI, E. FABIANOVA, V. CONSTANTINESCU, V. BENCKO, Lenka FORETOVÁ, V. JANOUT, N. CAPORASO, D. ALBANES, M. THUN, M. LANDI, J. TRUBICKA, M. LENER, J. LUBINSKI, Y. WANG, A. CHABRIER, P. BOFFETTA, P. BRENNAN and R. HUNG. International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. \textit{Carcinogenesis}. Oxford: Oxford University Press, 2010, vol.~31, No~4, p.~625-633. ISSN~0143-3334. Available from: https://dx.doi.org/10.1093/carcin/bgq001.
|
