| ŽUREK, Jiří, Ludmila BARTLOVÁ a Michal FEDORA. Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children. Brain Injury. London: Taylor & Francis, 2011, roč. 25, č. 2, s. 221-226. ISSN 0269-9052. Dostupné z: https://dx.doi.org/10.3109/02699052.2010.541895. |
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@article{925328,
author = {Žurek, Jiří and Bartlová, Ludmila and Fedora, Michal},
article_location = {London},
article_number = {2},
doi = {http://dx.doi.org/10.3109/02699052.2010.541895},
keywords = {Children; brain injury; biomarkers; outcome; hyperphosphorylated neurofilament},
language = {eng},
issn = {0269-9052},
journal = {Brain Injury},
title = {Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children},
volume = {25},
year = {2011}
}
TY - JOUR
ID - 925328
AU - Žurek, Jiří - Bartlová, Ludmila - Fedora, Michal
PY - 2011
TI - Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children
JF - Brain Injury
VL - 25
IS - 2
SP - 221-226
EP - 221-226
PB - Taylor & Francis
SN - 02699052
KW - Children
KW - brain injury
KW - biomarkers
KW - outcome
KW - hyperphosphorylated neurofilament
N2 - The aim of the study was to determine whether serum levels of hyperphosphorylated neurofilament NF-H correlate with severity of brain injury in children. Methods: Forty-nine patients with traumatic brain injury (TBI) were enrolled into the prospective study. Venous blood samples were taken after admission and every 24 h for a maximum of 6 consecutive days. Serum NF-H concentrations were quantified by enzyme-linked immunosorbent assay. The outcome was evaluated 6 months after TBI using Glasgow Outcome Scale (GOS) in all patients. Results: The quantitative level of pNF-H remained significantly higher in patients with poor outcome (GOS = 1) in comparison with the other patients for the 2nd-4th day (p = 0.027; p = 0.019; p = 0.01). Levels of pNF-H were significantly higher in patients with diffuse axonal injury on initial CT scan (p = 0.004). Normal levels pNF-H in the paediatric population are unknown. Objective ROC analysis was identification of optimal cut-offs of proteins for prediction of GOS = 1. Conclusions: Although further, prospective study is warranted, these findings suggest that levels of hyperphosphorylated neurofilament NF-H correlate with mortality and may be useful as predictors of outcome in children with TBI.
ER -
ŽUREK, Jiří, Ludmila BARTLOVÁ a Michal FEDORA. Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children. \textit{Brain Injury}. London: Taylor \&{} Francis, 2011, roč.~25, č.~2, s.~221-226. ISSN~0269-9052. Dostupné z: https://dx.doi.org/10.3109/02699052.2010.541895.
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