KÁRA, Tomáš, Miroslav NOVÁK and Miroslav SOUČEK. Use of a novel transfer function to reduce repolarization interval hysteresis. Journal of interventional cardiac electrophysiology. USA: Springer, 2010, vol. 29, No 1, p. 23-32. ISSN 1383-875X. Available from: https://dx.doi.org/10.1007/s10840-010-9500-x.
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Basic information
Original name Use of a novel transfer function to reduce repolarization interval hysteresis
Authors KÁRA, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Miroslav NOVÁK (203 Czech Republic, belonging to the institution) and Miroslav SOUČEK (203 Czech Republic, belonging to the institution).
Edition Journal of interventional cardiac electrophysiology, USA, Springer, 2010, 1383-875X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.228
RIV identification code RIV/00216224:14110/10:00047296
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s10840-010-9500-x
UT WoS 000281972600004
Keywords (in Czech) transfer funkce; repolarizace; hystereza
Keywords in English transfer function;repolarization; hysteresis
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 11/10/2012 09:28.
Abstract
Cardiac repolarization is assessed by the QT interval on the surface electrocardiogram and varies with the heart rate. Standard QT corrections (QTc) do not account for the lag in QT change following a change in heart rate (QT hysteresis). Our group has developed and tested a transfer function (TRF) model to assess the effectiveness of a dynamic model of QT/RR coupling in eliminating hysteresis. We studied three groups: group I, healthy volunteers (n = 23, 41 +/- 17 years); group II, hypertensive patients (n = 25, 45 +/- 11 years); and group III, patients in a predominately paced rhythm (n = 5, 75 +/- 6 years). To vary the heart rate, either exercise bicycling in the supine position (groups I and II) or manipulation of the pacemaker parameters (group III) was done. We then compared a dynamic TRF model with a model based on weighted averages of previous RR intervals. Two parameters were tested: root mean square (RMS) of the error signal between measured and computed QT and the elimination of hysteretic loops. TRF-based measurements eliminated hysteresis in 22/23 (95%) group I patients, 21/25 (84%) group II patients, and 4/5 (80%) group III patients. When hysteresis elimination was not complete, the QT drift that followed RR intervals was different before and after bicycling (100 ms). In these patients, the corresponding QT interval did not significantly change during this period. The TRF model was found superior to the other tested models with respect to both analyzed parameters (RMS and hysteresis elimination). The TRF model limited QT hysteresis in healthy, hypertensive, and pacemaker-dependent patients. In addition, an important finding of QT drift in patients with hypertension was identified. With further study in these and other diseased states, the TRF model may improve our ability to measure accurately cardiac repolarization and to determine arrhythmia risk.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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