Outcome in males with first-episode schizophrenia: 7-year
follow-up

J 2011

Outcome in males with first-episode schizophrenia: 7-year follow-up

ČEŠKOVÁ, Eva, Radovan PŘIKRYL a Tomáš KAŠPÁREK

Základní údaje

Originální název

Outcome in males with first-episode schizophrenia: 7-year follow-up

Název česky

Výsledky u mužů s první epizodou schizofrenie: 7 let poté

Autoři

ČEŠKOVÁ, Eva (203 Česká republika, garant, domácí), Radovan PŘIKRYL (203 Česká republika, domácí) a Tomáš KAŠPÁREK (203 Česká republika, domácí)

Vydání

The World Journal of Biological Psychiatry, Oslo, Taylor and Francis, 2011, 1562-2975

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.385

Kód RIV

RIV/00216224:14110/11:00051913

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3109/15622975.2010.518625

UT WoS

000286900400006

Klíčová slova česky

první epizoda schizofrenie; symptomy; dlouhodobé sledování; remise

Klíčová slova anglicky

first episode schizophrenia; symptoms; long term follow up; remission

Příznaky

Mezinárodní význam

Změněno: 12. 4. 2012 09:32, Mgr. Michal Petr

Anotace

ORIG CZ

V originále

Objectives. The early course of schizophrenia is highly variable. We assessed outcomes of patients with first-episode schizophrenia at 7-year follow-up. Methods. Consecutively hospitalized male patients were included if they were experiencing their first admission for first-episode schizophrenia and were reassessed at 1-, 4- and 7-year follow-ups. The psychopathology was evaluated using the PANSS, relative decrease of PANSS and remission status based on severity of core symptoms. Results. Forty-four of 76 patients were reassessed three times. At the end of index hospitalization 73% of patients achieved remission; however, after 1, 4 and 7 years, the percentage had dropped to 50, 50 and 52%, respectively. When compared post-hoc there was no significant difference in PANSS and response to treatment between remitters and non-remitters during the index hospitalization; however, a significant difference in psychopathology emerged first after 1, 4 and 7 years. All patients who had not achieve remission after 1 year also failed to achieve remission after 4 and 7 years. Conclusions. Response to treatment during the first psychotic break-through may not be a decisive indicator for the outlook of the disease. Our data suggest that when deterioration occurs, it does so early after the first episode.

Česky

Odpověď na léčbu v průběhu prvních epizod schizofrenie nemusí být rozhodujícím ukazatelem pro další průběh nemoci. Naše data ukazují, že pokud ke zhoršení dojde, stává se to brzy po první epizodě.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

ČEŠKOVÁ, Eva, Radovan PŘIKRYL a Tomáš KAŠPÁREK. Outcome in males with first-episode schizophrenia: 7-year follow-up. The World Journal of Biological Psychiatry. Oslo: Taylor and Francis, 2011, roč. 12, č. 1, s. 66-72. ISSN 1562-2975. Dostupné z: https://dx.doi.org/10.3109/15622975.2010.518625.

@article{927377,
   author = {Češková, Eva and Přikryl, Radovan and Kašpárek, Tomáš},
   article_location = {Oslo},
   article_number = {1},
   doi = {http://dx.doi.org/10.3109/15622975.2010.518625},
   keywords = {first episode schizophrenia; symptoms; long term follow up; remission},
   language = {eng},
   issn = {1562-2975},
   journal = {The World Journal of Biological Psychiatry},
   title = {Outcome in males with first-episode schizophrenia: 7-year follow-up},
   volume = {12},
   year = {2011}
}

TY  - JOUR
ID  - 927377
AU  - Češková, Eva - Přikryl, Radovan - Kašpárek, Tomáš
PY  - 2011
TI  - Outcome in males with first-episode schizophrenia: 7-year follow-up
JF  - The World Journal of Biological Psychiatry
VL  - 12
IS  - 1
SP  - 66-72
EP  - 66-72
PB  - Taylor and Francis
SN  - 15622975
KW  - first episode schizophrenia
KW  - symptoms
KW  - long term follow up
KW  - remission
N2  - Objectives. The early course of schizophrenia is highly variable. We assessed outcomes of patients with first-episode schizophrenia at 7-year follow-up. Methods. Consecutively hospitalized male patients were included if they were experiencing their first admission for first-episode schizophrenia and were reassessed at 1-, 4- and 7-year follow-ups. The psychopathology was evaluated using the PANSS, relative decrease of PANSS and remission status based on severity of core symptoms. Results. Forty-four of 76 patients were reassessed three times. At the end of index hospitalization 73% of patients achieved remission; however, after 1, 4 and 7 years, the percentage had dropped to 50, 50 and 52%, respectively. When compared post-hoc there was no significant difference in PANSS and response to treatment between remitters and non-remitters during the index hospitalization; however, a significant difference in psychopathology emerged first after 1, 4 and 7 years. All patients who had not achieve remission after 1 year also failed to achieve remission after 4 and 7 years. Conclusions. Response to treatment during the first psychotic break-through may not be a decisive indicator for the outlook of the disease. Our data suggest that when deterioration occurs, it does so early after the first episode.
ER  -

ČEŠKOVÁ, Eva, Radovan PŘIKRYL a Tomáš KAŠPÁREK. Outcome in males with first-episode schizophrenia: 7-year follow-up. \textit{The World Journal of Biological Psychiatry}. Oslo: Taylor and Francis, 2011, roč.~12, č.~1, s.~66-72. ISSN~1562-2975. Dostupné z: https://dx.doi.org/10.3109/15622975.2010.518625.

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