Detailed Information on Publication Record
2007
Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome
BRICHTOVÁ, Eva and Libor KOZÁKBasic information
Original name
Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome
Authors
BRICHTOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution) and Libor KOZÁK (203 Czech Republic, belonging to the institution)
Edition
Childs Nerv Syst, 2007, 0256-7040
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.993
RIV identification code
RIV/00216224:14110/07:00047349
Organization unit
Faculty of Medicine
UT WoS
000252888100011
Keywords in English
Brain injuries Child Apolipoprotein E4 Association Glasgow Coma Scale Glasgow Outcome Scale
Změněno: 27/2/2011 20:29, prof. MUDr. Eva Brichtová, Ph.D.
Abstract
V originále
To determine whether the presence of Apolipoprotein E 4 genotype (ApoE 4) is associated with outcomes of traumatic brain injury in children. The ApoE genotype was examined in the group of 70 pediatric patients who suffered from traumatic brain injury. The group consists of 48 boys and 22 girls, and the most frequent was the E3 isoform of ApoE. Polymerase chain reaction/restriction fragment length polymorphism method was used for the ApoE genotype assessment. Our results suggest the association between the ApoE genotype and outcome of traumatic brain injury in children. Patients with ApoE 4 genotype were more likely to have severe clinical symptomatology and unfavorable neurological outcome after traumatic brain injury compared to significantly better outcome with other ApoE genotype.