J 2007

Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome

BRICHTOVÁ, Eva and Libor KOZÁK

Basic information

Original name

Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome

Authors

BRICHTOVÁ, Eva (203 Czech Republic, guarantor, belonging to the institution) and Libor KOZÁK (203 Czech Republic, belonging to the institution)

Edition

Childs Nerv Syst, 2007, 0256-7040

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.993

RIV identification code

RIV/00216224:14110/07:00047349

Organization unit

Faculty of Medicine

UT WoS

000252888100011

Keywords in English

Brain injuries Child Apolipoprotein E4 Association Glasgow Coma Scale Glasgow Outcome Scale
Změněno: 27/2/2011 20:29, prof. MUDr. Eva Brichtová, Ph.D.

Abstract

V originále

To determine whether the presence of Apolipoprotein E 4 genotype (ApoE 4) is associated with outcomes of traumatic brain injury in children. The ApoE genotype was examined in the group of 70 pediatric patients who suffered from traumatic brain injury. The group consists of 48 boys and 22 girls, and the most frequent was the E3 isoform of ApoE. Polymerase chain reaction/restriction fragment length polymorphism method was used for the ApoE genotype assessment. Our results suggest the association between the ApoE genotype and outcome of traumatic brain injury in children. Patients with ApoE 4 genotype were more likely to have severe clinical symptomatology and unfavorable neurological outcome after traumatic brain injury compared to significantly better outcome with other ApoE genotype.