Interactions between the Nse3 and Nse4 Components of the SMC5-6
Complex Identify Evolutionarily Conserved Interactions between
MAGE and EID Families

J 2011

Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families

HUDSON, J J R, Kateřina BEDNÁŘOVÁ, Lucie KOZÁKOVÁ, Chunyan LIAO, Marc GUÉRINEAU et. al.

Základní údaje

Originální název

Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families

Název česky

Interakce mezi Nse3 a Nse4 podjednotkami SMC5-6 komplexu ukazují na evoluční konzervaci vazby mezi MAGE a EID proteinovými rodinami

Autoři

HUDSON, J J R (826 Velká Británie a Severní Irsko), Kateřina BEDNÁŘOVÁ (203 Česká republika, domácí), Lucie KOZÁKOVÁ (203 Česká republika, domácí), Chunyan LIAO (826 Velká Británie a Severní Irsko), Marc GUÉRINEAU (250 Francie, domácí), Rita COLNAGHI (826 Velká Británie a Severní Irsko), Susanne VIDOT (826 Velká Británie a Severní Irsko), Jaromír MAREK (203 Česká republika, domácí), Sreenivas Reddy BATHULA (356 Indie, domácí), Alan LEHMANN (826 Velká Británie a Severní Irsko) a Jan PALEČEK (203 Česká republika, garant, domácí)

Vydání

PloS ONE, San Francisco, Public Library of Science, 2011, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.092

Kód RIV

RIV/00216224:14740/11:00049415

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1371/journal.pone.0017270

UT WoS

000287764100039

Klíčová slova anglicky

SMC5-6 complex; Nse3/MAGE; Nse4/EID; genome stability; transcription regulation; evolution; placental mammals

Štítky

MAGE proteins, ok, rivok, SMC5-6 complex

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 1. 2017 11:39, doc. Mgr. Jan Paleček, Dr. rer. nat.

Anotace

V originále

The SMC5-6 protein complex is involved in the cellular response to DNA damage. It is composed of 6 - 8 polypeptides, of which Nse1, Nse3 and Nse4 form a tight sub-complex. MAGEG1, the mammalian ortholog of Nse3, is the founding member of the MAGE (melanoma-associated antigen) protein family and Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors. We have identified a conserved hydrophobic surface on the C-terminal domain of Nse3 that interacts with Nse4 and identified residues in its N-terminal domain that are essential for interaction with Nse1. We show that these interactions are conserved in the human orthologs. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that most MAGE proteins can interact with at least one of the NSE4/EID proteins.

Návaznosti

GD204/08/H054, projekt VaV

Název: Molekulární mechanismy proliferace a diferenciace buněk

Investor: Grantová agentura ČR, Molekulární mechanismy proliferace a diferenciace buněk

IAA501630902, projekt VaV

Název: Charakterizace MAGE proteinů: kofaktory E3 ubiquitin ligáz?

Investor: Akademie věd ČR, Charakterizace MAGE proteinů: kofaktory E3 ubiquitin ligáz?

MSM0021622415, záměr

Název: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární podstata buněčných a tkáňových regulací

Citovat

HUDSON, J J R, Kateřina BEDNÁŘOVÁ, Lucie KOZÁKOVÁ, Chunyan LIAO, Marc GUÉRINEAU, Rita COLNAGHI, Susanne VIDOT, Jaromír MAREK, Sreenivas Reddy BATHULA, Alan LEHMANN a Jan PALEČEK. Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families. PloS ONE. San Francisco: Public Library of Science, 2011, roč. 6, č. 2, s. "nestránkováno", 14 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0017270.

@article{928558,
   author = {Hudson, J J R and Bednářová, Kateřina and Kozáková, Lucie and Liao, Chunyan and Guérineau, Marc and Colnaghi, Rita and Vidot, Susanne and Marek, Jaromír and Bathula, Sreenivas Reddy and Lehmann, Alan and Paleček, Jan},
   article_location = {San Francisco},
   article_number = {2},
   doi = {http://dx.doi.org/10.1371/journal.pone.0017270},
   keywords = {SMC5-6 complex; Nse3/MAGE; Nse4/EID; genome stability; transcription regulation; evolution; placental mammals},
   language = {eng},
   issn = {1932-6203},
   journal = {PloS ONE},
   title = {Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families},
   url = {http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270},
   volume = {6},
   year = {2011}
}

TY  - JOUR
ID  - 928558
AU  - Hudson, J J R - Bednářová, Kateřina - Kozáková, Lucie - Liao, Chunyan - Guérineau, Marc - Colnaghi, Rita - Vidot, Susanne - Marek, Jaromír - Bathula, Sreenivas Reddy - Lehmann, Alan - Paleček, Jan
PY  - 2011
TI  - Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families
JF  - PloS ONE
VL  - 6
IS  - 2
SP  - "nestránkováno"
EP  - "nestránkováno"
PB  - Public Library of Science
SN  - 19326203
KW  - SMC5-6 complex
KW  - Nse3/MAGE
KW  - Nse4/EID
KW  - genome stability
KW  - transcription regulation
KW  - evolution
KW  - placental mammals
UR  - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270
L2  - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270
N2  - The SMC5-6 protein complex is involved in the cellular response to DNA damage. It is composed of 6 - 8 polypeptides, of which Nse1, Nse3 and Nse4 form a tight sub-complex. MAGEG1, the mammalian ortholog of Nse3, is the founding member of the MAGE (melanoma-associated antigen) protein family and Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors. We have identified a conserved hydrophobic surface on the C-terminal domain of Nse3 that interacts with Nse4 and identified residues in its N-terminal domain that are essential for interaction with Nse1. We show that these interactions are conserved in the human orthologs. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that most MAGE proteins can interact with at least one of the NSE4/EID proteins.
ER  -

HUDSON, J J R, Kateřina BEDNÁŘOVÁ, Lucie KOZÁKOVÁ, Chunyan LIAO, Marc GUÉRINEAU, Rita COLNAGHI, Susanne VIDOT, Jaromír MAREK, Sreenivas Reddy BATHULA, Alan LEHMANN a Jan PALEČEK. Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families. \textit{PloS ONE}. San Francisco: Public Library of Science, 2011, roč.~6, č.~2, s.~''nestránkováno'', 14 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0017270.

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