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@article{934942,
author = {Krejčí, Marta and Gregora, Evžen and Straub, Jan and Manařík, Jiří and Ščudla, Vlastimil and Adam, Zdeněk and Křivanová, Andrea and Pour, Luděk and Zahradová, Lenka and Büchler, Tomáš and Mayer, Jiří and Hájek, Roman},
article_location = {Berlin, Germany},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s00277-011-1206-3},
keywords = {Multiple myeloma; Bortezomib; Thalidomide},
language = {eng},
issn = {0939-5555},
journal = {Annals of hematology},
title = {Similar efficacy of thalidomide- and bortezomib-based regimens for first relapse of multiple myeloma},
volume = {90},
year = {2011}
}
TY - JOUR
ID - 934942
AU - Krejčí, Marta - Gregora, Evžen - Straub, Jan - Manařík, Jiří - Ščudla, Vlastimil - Adam, Zdeněk - Křivanová, Andrea - Pour, Luděk - Zahradová, Lenka - Büchler, Tomáš - Mayer, Jiří - Hájek, Roman
PY - 2011
TI - Similar efficacy of thalidomide- and bortezomib-based regimens for first relapse of multiple myeloma
JF - Annals of hematology
VL - 90
IS - 12
SP - 1441–1447
EP - 1441–1447
PB - Springer Verlag
SN - 09395555
KW - Multiple myeloma
KW - Bortezomib
KW - Thalidomide
N2 - Many regimens containing novel drugs have been developed for multiple myeloma (MM). It is not yet clear whether some of the novel agents are better than others. In a retrospective study, we have analyzed the outcomes of patients with first relapse of MM treated with thalidomide-based (T) regimens (n=105) or bortezomib-based (B) regimens (n=106). Both T and B groups were comparable regarding basic clinical parameters and first-line therapies. Combination of thalidomide with an alkylating drug (A) and dexamethasone (D) was used in 91 cases, T with D in five cases, and T alone in nine cases. A combination of bortezomib with A and D was used in 58 patients, B with D or A in 40 patients, and B alone in eight patients. In the T group, ORR was 51%, median TTP from the start of treatment for relapse of 13.1 months, and median OS of 30.4 months. In the B group, ORR was 50% with median TTP of 16.7 months and median OS of 37.2 months. No significant differences in ORR (p=0.774), TTP (p=0.207), or OS (p=0.889) were observed between the two groups. In conclusion, T and B-based regimens appear to be equally effective in the treatment of first MM relapse.
ER -
KREJČÍ, Marta, Evžen GREGORA, Jan STRAUB, Jiří MANAŘÍK, Vlastimil ŠČUDLA, Zdeněk ADAM, Andrea KŘIVANOVÁ, Luděk POUR, Lenka ZAHRADOVÁ, Tomáš BÜCHLER, Jiří MAYER a Roman HÁJEK. Similar efficacy of thalidomide- and bortezomib-based regimens for first relapse of multiple myeloma. \textit{Annals of hematology}. Berlin, Germany: Springer Verlag, 2011, roč.~90, č.~12, s.~1441–1447. ISSN~0939-5555. Dostupné z: https://dx.doi.org/10.1007/s00277-011-1206-3.
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