| POHANKA, Miroslav, Svatava SNOPKOVÁ, Kateřina HAVLÍČKOVÁ, Pavel BOŠTÍK, Zuzana ŠINKOROVÁ, Josef FUSEK, Kamil KUČA a Jiří PIKULA. Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway. Current Medicinal Chemistry. Sharjah: Betham Science Publ., 2011, roč. 18, č. 4, s. 539-551. ISSN 0929-8673. Dostupné z: https://dx.doi.org/10.2174/092986711794480140. |
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@article{934943,
author = {Pohanka, Miroslav and Snopková, Svatava and Havlíčková, Kateřina and Boštík, Pavel and Šinkorová, Zuzana and Fusek, Josef and Kuča, Kamil and Pikula, Jiří},
article_location = {Sharjah},
article_number = {4},
doi = {http://dx.doi.org/10.2174/092986711794480140},
keywords = {Innate immunity; cell; infection; parasympathetic nervous system; inflammation; tumour necrosis factor; acetylcholine receptor; acetylcholineesterase},
language = {eng},
issn = {0929-8673},
journal = {Current Medicinal Chemistry},
title = {Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway},
volume = {18},
year = {2011}
}
TY - JOUR
ID - 934943
AU - Pohanka, Miroslav - Snopková, Svatava - Havlíčková, Kateřina - Boštík, Pavel - Šinkorová, Zuzana - Fusek, Josef - Kuča, Kamil - Pikula, Jiří
PY - 2011
TI - Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway
JF - Current Medicinal Chemistry
VL - 18
IS - 4
SP - 539-551
EP - 539-551
PB - Betham Science Publ.
SN - 09298673
KW - Innate immunity
KW - cell
KW - infection
KW - parasympathetic nervous system
KW - inflammation
KW - tumour necrosis factor
KW - acetylcholine receptor
KW - acetylcholineesterase
N2 - Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP) associated with the nicotinic acetylcholine receptor (nAChR) and the parasympathetic nervous system. The current pharmacological effectiveness in suppressing the inflammation in general and the septic shock in particular, is limited. CAP was discovered recently and it seems to be a suitable target for the development of new drugs. Moreover, available drugs binding to either nAChR or acetylcholinesterase (AChE) are candidates for either an inhibition or enhancement of CAP. Though the current scientific databases do not include all necessary data on the association of CAP with body functions and the research is quite intensive, the objective of the present review is to introduce the current trends and to critically evaluate CAP and macrophage-associated pathways.
ER -
POHANKA, Miroslav, Svatava SNOPKOVÁ, Kateřina HAVLÍČKOVÁ, Pavel BOŠTÍK, Zuzana ŠINKOROVÁ, Josef FUSEK, Kamil KUČA a Jiří PIKULA. Macrophage-Assisted Inflammation and Pharmacological Regulation of the Cholinergic Anti-Inflammatory Pathway. \textit{Current Medicinal Chemistry}. Sharjah: Betham Science Publ., 2011, roč.~18, č.~4, s.~539-551. ISSN~0929-8673. Dostupné z: https://dx.doi.org/10.2174/092986711794480140.
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