FALTEJSKOVÁ, Petra, Renata HÉŽOVÁ, Marek SVOBODA, Jiří ŠÁNA, Lenka RADOVÁ, Radim NĚMEČEK, Andrej BEŠŠE, Rostislav VYZULA and Ondřej SLABÝ. Detection of metastatic spread to lymph nodes in colorectal cancer patients by analysis of microRNA expression profiles in primary tumors. In The Student Scientific Conference on Cancer Research. 2011. ISBN 978-80-210-5442-4.
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Basic information
Original name Detection of metastatic spread to lymph nodes in colorectal cancer patients by analysis of microRNA expression profiles in primary tumors.
Authors FALTEJSKOVÁ, Petra, Renata HÉŽOVÁ, Marek SVOBODA, Jiří ŠÁNA, Lenka RADOVÁ, Radim NĚMEČEK, Andrej BEŠŠE, Rostislav VYZULA and Ondřej SLABÝ.
Edition The Student Scientific Conference on Cancer Research, 2011.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Organization unit Masaryk Memorial Cancer Institute
ISBN 978-80-210-5442-4
Keywords (in Czech) mikroRNA, kolorektální karcinom
Keywords in English microRNA, colorectal cancer
Changed by Changed by: Mgr. Petra Vychytilová, Ph.D., učo 211789. Changed: 10/3/2012 10:09.
Abstract
The aim of this study was molecular characterization of primary tumors of colon and rectum using modern and progressive analysis based on expression profiles of 667 microRNAs by quantitative real-time PCR arrays. We analyzed expression profiles of 20 patients without lymph node positivity and 25 patients with lymph node positivity to identify miRNA differentially expressed between these two groups that would alow us to diagnose presence of lymph nodes metastases directly from the primary tumor.
Links
MZ0MOU2005, plan (intention)Name: Funkční diagnostika zhoubných nádorů
NS10352, research and development projectName: Význam mikroRNA v chemoprotektivním účinku fytochemikálií zeleniny rodu Brassica a vliv polymorfizmů jejich vazebných míst na riziko nádorového onemocnění tlustého střeva a konečníku
NS9814, research and development projectName: Identifikace a studium funkce mikroRNA s prediktivním a prognostickým významen u pacientů se zhoubným novotvarem tlustého střeva a konečníku
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