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@proceedings{941086,
author = {Castillo, Gabriela and Trnková, Libuše and Foguel, Marcos Vinicius and Hianik, Tibor},
booktitle = {XXI INTERNATIONAL SYMPOSIUM ON BIOELECTROCHEMISTRY AND BIOENERGETICS},
keywords = {DNA;RNA;aptamers;thrombin;gold cd;electrochemical impedance},
language = {eng},
isbn = {978-83-62139-23-1},
title = {APTAMER BASED CD-SENSORS FOR THROMBIN RECOGNITION BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY},
year = {2011}
}
TY - CONF
ID - 941086
AU - Castillo, Gabriela - Trnková, Libuše - Foguel, Marcos Vinicius - Hianik, Tibor
PY - 2011
TI - APTAMER BASED CD-SENSORS FOR THROMBIN RECOGNITION BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY
SN - 9788362139231
KW - DNA;RNA;aptamers;thrombin;gold cd;electrochemical impedance
N2 - Biosensors based on DNA or RNA aptamers, represent a very efficient platform for protein recognition1. We developed a novel label-free aptamer biosensing array for thrombin detection by measuring the electrochemical impedance upon aptamer-protein complex formation using gold CD-trodes (GCDT). GCDT are electrodes fabricated from recordable compact discs that contain a fine gold layer on their surface. Low-cost GCDTs present good versatility and acceptable reproducibility. The thrombin biosensor is constructed by self-assembling a thiol-modified aptamer onto a GCDT surface, followed by recognition of the protein via monitoring the interfacial electron transfer resistance in the presence of an [Fe(CN)6]3-/4- redox couple2,3. The aptasensor was also characterized by cyclic voltammetry and the individual binding steps were analysed by scanning electron microscopy.
ER -
CASTILLO, Gabriela, Libuše TRNKOVÁ, Marcos Vinicius FOGUEL a Tibor HIANIK. APTAMER BASED CD-SENSORS FOR THROMBIN RECOGNITION BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY. In \textit{XXI INTERNATIONAL SYMPOSIUM ON BIOELECTROCHEMISTRY AND BIOENERGETICS}. 2011. ISBN~978-83-62139-23-1.
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