WEBER, Pavel, Petronela AMBROŠOVÁ, Petr CANOV, Dana WEBEROVÁ, Pavel KUKLÍNEK, Hana MELUZÍNOVÁ and Hana MATĚJOVSKÁ KUBEŠOVÁ. GAD antibodies in T1D and LADA - relation to age, BMI, C-peptide, IA-2and HLA DRB1*03 AND DRB1*04 alleles (LADA antibodies in T1D and LADA - relation to age, BMI, C-peptide, IA-2and HLA DRB1*03 AND DRB1*04 alleles). Advances in Gerontology / Uspekhi Gerontologii. 2011, vol. 24, No 2, p. 312-318. ISSN 1561-9125.
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Basic information
Original name GAD antibodies in T1D and LADA - relation to age, BMI, C-peptide, IA-2and HLA DRB1*03 AND DRB1*04 alleles
Name in Czech GAD protilátek v T1D a LADA - vzhledem k věku, BMI, C-peptid, IA-2and HLA DRB1 * 03 a DRB1 * 04
Authors WEBER, Pavel (203 Czech Republic, guarantor, belonging to the institution), Petronela AMBROŠOVÁ (703 Slovakia, belonging to the institution), Petr CANOV (203 Czech Republic, belonging to the institution), Dana WEBEROVÁ (203 Czech Republic, belonging to the institution), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Hana MELUZÍNOVÁ (203 Czech Republic, belonging to the institution) and Hana MATĚJOVSKÁ KUBEŠOVÁ (203 Czech Republic, belonging to the institution).
Edition Advances in Gerontology / Uspekhi Gerontologii, 2011, 1561-9125.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Russian Federation
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/11:00052473
Organization unit Faculty of Medicine
Keywords in English GAD antibodies; diabetes mellitus
Changed by Changed by: prof. MUDr. Pavel Weber, CSc., učo 37287. Changed: 2/2/2013 17:02.
Abstract
The determination of GADA may be useful for clinical classification of diabetes mellitus(DM) in clinically unclear cases. This GADA positivity may in any diabetics Type 1 diabetes Mellitus (T1D) with an onset in adulthood and Late Autoimmune Diabetes of Adults(LADA) persist many years after appearance of DM. The study was aimed at comparing the levels of GADA between both diabetic subsets with their clinical parameters, age of onset DM, perod of insulin need, body mass index, HbA1C, fasting and postprandial C-peptide, risky HLA-DRB1* alleles, occurrence of micro-and macrovascular diabetic complications.
Abstract (in Czech)
Stanovení GADA mohou být užitečné pro klinické klasifikaci diabetes mellitus (DM) v klinicky nejasných případech. Tato pozitivita GADA může v každém diabetiků 1. typu diabetes mellitus (T1D) s nástupem v dospělosti a pozdní autoimunitní diabetes dospělých (LADA) přetrvávat mnoho let po výskytu DM. Studie byla zaměřena na srovnání úrovně GADA obou diabetických podskupin s jejich klinickými parametry, věk nástupu DM, period inzulínu potřeba, index tělesné hmotnosti, HbA1C, nalačno a po jídle C-peptid, rizikové HLA-DRB1 * alel, výskyt mikro-a makrovaskulárních komplikací diabetu.
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