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@proceedings{943462,
author = {Kryukov, Fedor and Němec, Pavel and Dementyeva, Elena Vladimirovna and Ševčíková, Sabina and Almáši, Martina and Smetana, Jan and Kuglík, Petr and Hájek, Roman},
booktitle = {16th Congress of the European Hematology Association},
keywords = {centrosome; multiple myeloma; plasma cell; genome},
language = {eng},
title = {Centrosome associated genes in multiple myeloma},
year = {2011}
}
TY - CONF
ID - 943462
AU - Kryukov, Fedor - Němec, Pavel - Dementyeva, Elena Vladimirovna - Ševčíková, Sabina - Almáši, Martina - Smetana, Jan - Kuglík, Petr - Hájek, Roman
PY - 2011
TI - Centrosome associated genes in multiple myeloma
KW - centrosome
KW - multiple myeloma
KW - plasma cell
KW - genome
N2 - Multiple myeloma (MM) is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells within the bone marrow. The genome of malignant plasma cells is extremely unstable characterized by a complex combination of structural and numerical abnormalities. It is suggested that centrosome abnormalities, of which centrosome amplification is the most prominent, occur early in MM pathogenesis and increase with disease progression. Centrosome amplification is therefore associated with deregulation of cell cycle, mitosis, DNA repair and proliferation. The objective of our study was to evaluate changes in expression profile of genes involved in centrosome structure/function in MM with known role in oncogenesis.In our study, we showed distinct cluster of 36 mitotic genes involved in centrosome abnormality in MM. Similarity of expression profile in revealed cluster gives us the possibility to suspect that these genes are involved in MM cell oncogenesis as a whole complex. This fact needs more detailed investigation and in our futher work we anticipate new insights into pathogenesis and possible crucial role of centrosome abnormalities in myeloma malignancy.
ER -
KRYUKOV, Fedor, Pavel NĚMEC, Elena Vladimirovna DEMENTYEVA, Sabina ŠEVČÍKOVÁ, Martina ALMÁŠI, Jan SMETANA, Petr KUGLÍK a Roman HÁJEK. Centrosome associated genes in multiple myeloma. In \textit{16th Congress of the European Hematology Association}. 2011. ISSN~0390-6078.
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