Visfatin is secreted into the breast milk and is correlated with weight changes of the infant after the birth

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Filip ZLÁMAL, Josef TOMANDL, Marie TOMANDLOVÁ, Zuzana DOSTÁLOVÁ and Anna VAŠKŮ. Visfatin is secreted into the breast milk and is correlated with weight changes of the infant after the birth. Diabetes Research and Clinical Practice. Ireland: Elsevier Ireland, 2012, vol. 96, No 3, p. 355-361. ISSN 0168-8227. Available from: https://dx.doi.org/10.1016/j.diabres.2011.06.009.

Basic information

Original name

Visfatin is secreted into the breast milk and is correlated with weight changes of the infant after the birth

Name in Czech

Visfatin je secernován do mateřského mléka a koreluje s hmotnostními změnami kojence po porodu

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Marie TOMANDLOVÁ (203 Czech Republic, belonging to the institution), Zuzana DOSTÁLOVÁ (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

Diabetes Research and Clinical Practice, Ireland, Elsevier Ireland, 2012, 0168-8227

---

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.741

RIV identification code

RIV/00216224:14110/12:00059030

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.diabres.2011.06.009

UT WoS

000305281100024

Keywords (in Czech)

visfatin; mateřské mléko; tuková tkáň; hmotnost kojence

Keywords in English

visfatin; breast milk; adiposity; infant weight

Tags

International impact

---

Abstract

V originále

Visfatin is a recently identified adipokine with numerous metabolic and immunoregulatory properties that has been implicated in the regulation of the white adipose tissue (WAT) and significant changes in visfatin levels were reported during pregnancy. The aim of the study was to investigate dynamics of visfatin levels in maternal serum and human breast milk during a 180-d period after the delivery. Breast milk and venous blood samples were obtained from 24 healthy lactating women with uncomplicated, physiological pregnancy and appropriate- for-gestational age neonates and serum–milk sample duos were collected at the time of birth, at the 1–3, 12–14, 28–30, 88–90 and 178–180 postpartum. Our study demonstrates that (1) visfatin is abundantly secreted into breast milk in humans, reaching approx. 100x higher concentrations compared to maternal serum; (2) visfatin concentrations in maternal serum show significant variations after the delivery and (3) visfatin concentration in colostrum could be used for prediction of the subsequent weight development (less/more severe weight loss during first 3 days after the birth) of the infant. Our data suggest that visfatin could play an important role in regulation of adiposity of the infatn after the birth.

In Czech

První dosud publikovaná studie popisující uvolňování visfatinu do mateřského mléka během celého 180-denního poporodního období. Dále demonstrujeme, že hladina visfatinu v mateřském mléce může být použita pro predikci hmotnostního vývoje kojence v časném poporodním období.