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@article{947102,
author = {Stixová, Lenka and Bártová, Eva and Matula, Pavel and Daněk, Ondřej and Legartová, Soňa and Kozubek, Stanislav},
article_number = {5},
doi = {http://dx.doi.org/10.1186/1756-8935-4-5},
keywords = {protein dynamics HP1b BMI1 TRF1 trajectory heterochromatin},
language = {eng},
issn = {1756-8935},
journal = {Epigenetics & Chromatin},
title = {Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin},
url = {http://www.epigeneticsandchromatin.com/content/4/1/5},
volume = {4},
year = {2011}
}
TY - JOUR
ID - 947102
AU - Stixová, Lenka - Bártová, Eva - Matula, Pavel - Daněk, Ondřej - Legartová, Soňa - Kozubek, Stanislav
PY - 2011
TI - Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin
JF - Epigenetics & Chromatin
VL - 4
IS - 5
SP - 1-17
EP - 1-17
SN - 17568935
KW - protein dynamics HP1b BMI1 TRF1 trajectory heterochromatin
UR - http://www.epigeneticsandchromatin.com/content/4/1/5
L2 - http://www.epigeneticsandchromatin.com/content/4/1/5
N2 - We show that protein dynamics are influenced by many factors and events, including nuclear pattern and transcription activity. A slower recovery after photobleaching was found when proteins, such as HP1b, BMI1, TRF1, and others accumulated at specific foci. In identical cells, proteins that were evenly dispersed throughout the nucleoplasm recovered more rapidly. Distinct trajectories for HP1b, BMI1, and TRF1 were observed after hyperacetylation or suppression of transcription. The relationship between protein trajectory and transcription level was confirmed for telomeric protein TRF1, but not for HP1b or BMI1 proteins. Moreover, heterogeneity of foci movement was especially observed when we made distinctions between centrally and peripherally positioned foci. Based on our results, we propose that protein kinetics are likely influenced by several factors, including chromatin condensation, differentiation, local protein density, protein binding efficiency, and nuclear pattern. These factors and events likely cooperate to dictate the mobility of particular proteins.
ER -
STIXOVÁ, Lenka, Eva BÁRTOVÁ, Pavel MATULA, Ondřej DANĚK, Soňa LEGARTOVÁ a Stanislav KOZUBEK. Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin. \textit{Epigenetics \&{} Chromatin}. 2011, roč.~4, č.~5, s.~1-17. ISSN~1756-8935. Dostupné z: https://dx.doi.org/10.1186/1756-8935-4-5.
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