| HOŠEK, Jan, Milan BARTOS, Stanislav CHUDÍK, Stefano DALL’ACQUA, Gabbriella INNOCENTI, Murat KARTAL, Ladislav KOKOŠKA, Peter KOLLÁR, Zsófia KUTIL, Přemysl LANDA, Radek MAREK, Veronika ZÁVALOVÁ, Milan ŽEMLIČKA and Karel ŠMEJKAL. Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro. Journal of Natural Products. American Chemical Society, 2011, vol. 74, No 4, p. 614-619. ISSN 0163-3864. Available from: https://dx.doi.org/10.1021/np100638h. |
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@article{947522,
author = {Hošek, Jan and Bartos, Milan and Chudík, Stanislav and Dall’Acqua, Stefano and Innocenti, Gabbriella and Kartal, Murat and Kokoška, Ladislav and Kollár, Peter and Kutil, Zsófia and Landa, Přemysl and Marek, Radek and Závalová, Veronika and Žemlička, Milan and Šmejkal, Karel},
article_number = {4},
doi = {http://dx.doi.org/10.1021/np100638h},
keywords = {Cudraflavone; Morus alba; anti-inflammatory; zinc-finger protein; nonsteroidal drug lead},
language = {eng},
issn = {0163-3864},
journal = {Journal of Natural Products},
title = {Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro},
url = {http://dx.doi.org/10.1021/np100638h},
volume = {74},
year = {2011}
}
TY - JOUR
ID - 947522
AU - Hošek, Jan - Bartos, Milan - Chudík, Stanislav - Dall’Acqua, Stefano - Innocenti, Gabbriella - Kartal, Murat - Kokoška, Ladislav - Kollár, Peter - Kutil, Zsófia - Landa, Přemysl - Marek, Radek - Závalová, Veronika - Žemlička, Milan - Šmejkal, Karel
PY - 2011
TI - Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
JF - Journal of Natural Products
VL - 74
IS - 4
SP - 614-619
EP - 614-619
PB - American Chemical Society
SN - 01633864
KW - Cudraflavone
KW - Morus alba
KW - anti-inflammatory
KW - zinc-finger protein
KW - nonsteroidal drug lead
UR - http://dx.doi.org/10.1021/np100638h
L2 - http://dx.doi.org/10.1021/np100638h
N2 - Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models. Thus, 1 was identified as a potent inhibitor of tumor necrosis factor R (TNFR) gene expression and secretion by blocking the translocation of nuclear factor kB (NF-kB) from the cytoplasm to the nucleus inmacrophages derived from a THP-1 human monocyte cell line. Compound 1 acts as a cyclooxygenase (COX-2 and COX-1) inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreatment of cells by 1 shifted the peak in an regulatory gene zinc-finger protein 36 (ZFP36) expression assay. This natural product has noticeable antiinflammatory properties, suggesting that 1 potentially could be used for development as a nonsteroidal anti-inflammatory drug lead.
ER -
HOŠEK, Jan, Milan BARTOS, Stanislav CHUDÍK, Stefano DALL’ACQUA, Gabbriella INNOCENTI, Murat KARTAL, Ladislav KOKOŠKA, Peter KOLLÁR, Zsófia KUTIL, Přemysl LANDA, Radek MAREK, Veronika ZÁVALOVÁ, Milan ŽEMLIČKA and Karel ŠMEJKAL. Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro. \textit{Journal of Natural Products}. American Chemical Society, 2011, vol.~74, No~4, p.~614-619. ISSN~0163-3864. Available from: https://dx.doi.org/10.1021/np100638h.
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