CECIONI, Samy, Sophie FAURE, Ulrich DARBOST, Isabelle BONNAMOUR, Helene PARROT-LOPEZ, Olivier ROY, Claude TAILLEFUMIER, Michaela WIMMEROVÁ, Jean-Pierre PRALY, Anne IMBERTY a Sebastien VIDAL. Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters. Chemistry - A European Journal. WILEY-VCH, 2011, roč. 17, č. 7, s. 2146–2159. ISSN 0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.201002635. |
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@article{947554, author = {Cecioni, Samy and Faure, Sophie and Darbost, Ulrich and Bonnamour, Isabelle and ParrotandLopez, Helene and Roy, Olivier and Taillefumier, Claude and Wimmerová, Michaela and Praly, JeanandPierre and Imberty, Anne and Vidal, Sebastien}, article_number = {7}, doi = {http://dx.doi.org/10.1002/chem.201002635}, keywords = {lectin; glycocluster;SPR;ITC}, language = {eng}, issn = {0947-6539}, journal = {Chemistry - A European Journal}, title = {Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters}, volume = {17}, year = {2011} }
TY - JOUR ID - 947554 AU - Cecioni, Samy - Faure, Sophie - Darbost, Ulrich - Bonnamour, Isabelle - Parrot-Lopez, Helene - Roy, Olivier - Taillefumier, Claude - Wimmerová, Michaela - Praly, Jean-Pierre - Imberty, Anne - Vidal, Sebastien PY - 2011 TI - Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters JF - Chemistry - A European Journal VL - 17 IS - 7 SP - 2146–2159 EP - 2146–2159 PB - WILEY-VCH SN - 09476539 KW - lectin KW - glycocluster;SPR;ITC N2 - We have designed a series of multivalent galactosylated glycoconjugates and studied their binding properties towards two lectins, from plant and bacterial origins, to determine their potential selectivity. The synthesis was achieved through copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) under microwave activation between propargylated multivalent scaffolds and an azido-functionalised carbohydrate derivative. The interactions of two galactose-binding lectins from Pseudomonas aeruginosa (PA-IL) and Erythrina cristagalli (ECA) with the synthesized glycoclusters were studied by hemagglutination inhibition assays (HIA), surface plasmon resonance (SPR) and isothermal titration microcalorimetry (ITC). The results obtained illustrate the influence of the scaffold's geometry on the affinity towards the lectin and also on the relative potency in comparison with a monovalent galactoside reference probe. ER -
CECIONI, Samy, Sophie FAURE, Ulrich DARBOST, Isabelle BONNAMOUR, Helene PARROT-LOPEZ, Olivier ROY, Claude TAILLEFUMIER, Michaela WIMMEROVÁ, Jean-Pierre PRALY, Anne IMBERTY a Sebastien VIDAL. Selectivity among Two Lectins: Probing the Effect of Topology, Multivalency and Flexibility of “Clicked” Multivalent Glycoclusters. \textit{Chemistry - A European Journal}. WILEY-VCH, 2011, roč.~17, č.~7, s.~2146–2159. ISSN~0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.201002635.
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