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@article{948313,
author = {Westenberg, J.J. and Scholte, A. J. and Vašková, Zuzana and van der Geest, R. J. and Groenink, M. and Labadie, G. and van den Boogaard, P. J. and Radonic, T. and HilhorstandHofstee, Y. and Mulder, B.J. and Kroft, L. J. and Reiber, J. H. and de Roos, A.},
article_number = {3},
doi = {http://dx.doi.org/10.1002/jmri.22646},
keywords = {magnetic resonance imaging; aortic stiffness; Marfan syndrome; elasticity; aging},
language = {eng},
issn = {1053-1807},
journal = {Journal of Magnetic Resonance Imaging},
title = {Age-related and regional changes of aortic stiffness in the marfan syndrome: Assessment with velocity-encoded MRI},
url = {http://onlinelibrary.wiley.com/doi/10.1002/jmri.22646/abstract},
volume = {34},
year = {2011}
}
TY - JOUR
ID - 948313
AU - Westenberg, J.J. - Scholte, A. J. - Vašková, Zuzana - van der Geest, R. J. - Groenink, M. - Labadie, G. - van den Boogaard, P. J. - Radonic, T. - Hilhorst-Hofstee, Y. - Mulder, B.J. - Kroft, L. J. - Reiber, J. H. - de Roos, A.
PY - 2011
TI - Age-related and regional changes of aortic stiffness in the marfan syndrome: Assessment with velocity-encoded MRI
JF - Journal of Magnetic Resonance Imaging
VL - 34
IS - 3
SP - 526-531
EP - 526-531
PB - Elsevier
SN - 10531807
KW - magnetic resonance imaging
KW - aortic stiffness
KW - Marfan syndrome
KW - elasticity
KW - aging
UR - http://onlinelibrary.wiley.com/doi/10.1002/jmri.22646/abstract
N2 - Purpose: To study age-related change in aortic stiffness in patients with Marfan syndrome (MFS) versus healthy volunteers using velocity-encoded (VE) MRI. Materials and Methods: Twenty-five MFS patients (age range, 18-63 years; mean age 36 +/- 14 years, 13 men) and 25 age-/gender-matched healthy volunteers were examined with VE-MRI. Aortic stiffness was expressed by pulse wave velocity (PWV), assessed in the proximal and distal part of the aorta and in the total aorta. PWV was compared between patients and volunteers and age-relation was determined by linear regression. Results: PWV was significantly higher in all parts of the aorta in patients when compared with healthy volunteers (proximal aorta 5.7 +/- 1.5 m/s versus 4.8 +/- 0.9 m/s, distal aorta 6.4 +/- 2.4 m/s versus 5.0 +/- 1.2 m/s and total aorta 5.9 +/- 1.7 m/s versus 4.9 +/- 1.1 m/s, all P < 0.004). PWV correlated significantly with age (Pearson R between 0.45 and 0.94). Only in the proximal aorta, the increase in PWV with age was significantly higher in patients (7 +/- 2 cm/s increase with age) than in volunteers (3 +/- 1 cm/s Increase, P = 0.03); in the distal or total aorta, the increase in PWV with age was not different between patients and volunteers. Conclusion: Velocity-encoded MRI detects more pronounced age-related aortic stiffening in the proximal aorta in MFS patients versus healthy volunteers, suggesting more severe wall disease in MFS.
ER -
WESTENBERG, J.J., A. J. SCHOLTE, Zuzana VAŠKOVÁ, R. J. VAN DER GEEST, M. GROENINK, G. LABADIE, P. J. VAN DEN BOOGAARD, T. RADONIC, Y. HILHORST-HOFSTEE, B.J. MULDER, L. J. KROFT, J. H. REIBER a A. DE ROOS. Age-related and regional changes of aortic stiffness in the marfan syndrome: Assessment with velocity-encoded MRI. \textit{Journal of Magnetic Resonance Imaging}. Elsevier, 2011, roč.~34, č.~3, s.~526-531. ISSN~1053-1807. Dostupné z: https://dx.doi.org/10.1002/jmri.22646.
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