Enhancement of psychostimulant effect and development of behavioural sensitisation to methamphetamine in mice by combined treatment with piracetam

MÁCHALOVÁ, Alena, Karel ŠLAIS, Dagmar VRŠKOVÁ and Alexandra ŠULCOVÁ. Enhancement of psychostimulant effect and development of behavioural sensitisation to methamphetamine in mice by combined treatment with piracetam. Activitas Nervosa Superior Rediviva. Collegium Internationale Activitatis N.S, 2011, vol. 2011, No 53, p. 27-31. ISSN 1337-933X.

Basic information

• Original name: Enhancement of psychostimulant effect and development of behavioural sensitisation to methamphetamine in mice by combined treatment with piracetam
• Name in Czech: Posílení psychostimulačního efektu metamfetaminu a rozvoje behaviorální senzitizace k jeho účinkům kombinovaným podáváním piracetamu
• Authors: MÁCHALOVÁ, Alena (203 Czech Republic, guarantor, belonging to the institution), Karel ŠLAIS (203 Czech Republic, belonging to the institution), Dagmar VRŠKOVÁ (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Activitas Nervosa Superior Rediviva, Collegium Internationale Activitatis N.S, 2011, 1337-933X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/11:00052903
• Organization unit: Faculty of Medicine
• Keywords (in Czech): metamfetamin; piracetam; behaviorální senzitizace; myš; test otevřeného pole
• Keywords in English: methamphetamine; piracetam; behavioural sensitisation; mice; open field test

Abstract

Piracetam in our experiment enhanced acute effects of methamphetamine as well as development of sensitisation to its stimulatory effects. Background of these pharmacological drug-drug interactions remains unclear. Although clinically piracetam itself shows minimal adverse effects and toxicity, its combination with methamphetamine could worsen the negative drug abuse consequences.

Abstract (in Czech)

Piracetam v našem experimentu posílil akutní účinky metamfetaminu stejně jako rozvoj behaviorální senzitizace k jeho stimulačním účinkům. Pozadí těchto farmakologických drug-drug interakcí není známé. Přestože klinicky piracetam vykazuje minimum nežádoucích a toxických účinků, jeho kombinace s metamfetaminem může zhoršit negativní dopady zneužívání této látky.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.