| JUŘICA, Jan, Ondřej ZENDULKA, Roman TRUBAČ a Alexandra ŠULCOVÁ. Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver. Activitas Nervosa Superior Rediviva. Praha: Collegium Internationale Activitatis N.S, 2011, roč. 53, č. 1, s. 32-34. ISSN 1337-933X. |
Další formáty:
BibTeX
LaTeX
RIS
@article{948342,
author = {Juřica, Jan and Zendulka, Ondřej and Trubač, Roman and Šulcová, Alexandra},
article_location = {Praha},
article_number = {1},
keywords = {raclopride; cytochrome P450; isolated perfused rat liver},
language = {eng},
issn = {1337-933X},
journal = {Activitas Nervosa Superior Rediviva},
title = {Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver},
url = {http://www.rediviva.sav.sk/53i1/32.pdf},
volume = {53},
year = {2011}
}
TY - JOUR
ID - 948342
AU - Juřica, Jan - Zendulka, Ondřej - Trubač, Roman - Šulcová, Alexandra
PY - 2011
TI - Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver
JF - Activitas Nervosa Superior Rediviva
VL - 53
IS - 1
SP - 32-34
EP - 32-34
PB - Collegium Internationale Activitatis N.S
SN - 1337933X
KW - raclopride
KW - cytochrome P450
KW - isolated perfused rat liver
UR - http://www.rediviva.sav.sk/53i1/32.pdf
L2 - http://www.rediviva.sav.sk/53i1/32.pdf
N2 - Our study addressed whether systemic administration of raclopride (D2 receptor antagonist) may influence the metabolic activity of rat CYP1A2, CYP2C6/11 or CYP2D2 in the model of isolated perfused liver. It was taken into consideration that CYP2C6/11 is a rat orthologue of human CYP2C9 (Matuskova et al 2009), CYP2D1 is rat orthologue of human CYP2D6 (Soucek & Gut 1992). The most used marker of CYP2D6 dextromethorphan is metabolized by CYP2D2 in rats (Kobayashi et al 2002). The model of isolated perfused rat liver was selected because it reflects most of physiological and biochemical linkages in the liver-mediated metabolism of xenobiotics
ER -
JUŘICA, Jan, Ondřej ZENDULKA, Roman TRUBAČ a Alexandra ŠULCOVÁ. Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver. \textit{Activitas Nervosa Superior Rediviva}. Praha: Collegium Internationale Activitatis N.S, 2011, roč.~53, č.~1, s.~32-34. ISSN~1337-933X.
|
