Bilateral changes of IL-10 protein in lumbar and cervical
dorsal root ganglia following proximal and distal chronic
constriction injury of peripheral nerve

J 2011

Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve

JANČÁLEK, Radim, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ a Petr DUBOVÝ

Základní údaje

Originální název

Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve

Autoři

JANČÁLEK, Radim (203 Česká republika, domácí), Ivana HRADILOVÁ SVÍŽENSKÁ (203 Česká republika, domácí), Ilona KLUSÁKOVÁ (203 Česká republika, domácí) a Petr DUBOVÝ (203 Česká republika, garant, domácí)

Vydání

Neuroscience Letters, Elsevier Ireland Ltd. 2011, 0304-3940

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.105

Kód RIV

RIV/00216224:14740/11:00053053

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.neulet.2011.06.052

UT WoS

000294317600006

Klíčová slova anglicky

Nerve injury; Cytokines; Neuroinflammation; Sham operation

Štítky

ok, rivok

Příznaky

Mezinárodní význam

Změněno: 24. 6. 2015 14:58, prof. RNDr. Petr Dubový, CSc.

Anotace

V originále

Interleukin-10 prevents transition of a physiological inflammatory reaction to a pathological state that may result in neuropathic pain. We studied bilateral changes of IL-10 in L4–L5 and C7–C8 dorsal root ganglia (DRG) after a chronic constriction injury (CCI) of spinal nerves or the sciatic nerve. Rats were left to survive for 1,3,7 or 14d, sham-operated for 3 or 14 d. IL-10 was detected by immunohistochemical staining and measured using ELISA analysis. Unilateral CCI induced a transient bilateral elevation in IL-10 not only in the homonymous lumbar but also in the heteronymous cervical DRG. Sham operations also induced bilateral elevation of IL-10 in both homonymous and heteronymous DRG. Our experiments revealed that the more proximal is a nerve injury the more rapid is the initial increase and slower the subsequent decrease of IL-10 in DRG. Changes of IL-10 in nonassociated DRG could be related to a general neuroinflammatory reaction of the nervous system to injury and thereby promote potential of the DRG neurons for regenerating their axons following a conditioning lesion.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Přiložené soubory

IL10NSL28174.pdf

Požádat o autorskou verzi souboru

Citovat

JANČÁLEK, Radim, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ a Petr DUBOVÝ. Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve. Neuroscience Letters. Elsevier Ireland Ltd., 2011, roč. 501, č. 2, s. 86-91. ISSN 0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2011.06.052.

@article{949872,
   author = {Jančálek, Radim and Hradilová Svíženská, Ivana and Klusáková, Ilona and Dubový, Petr},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.neulet.2011.06.052},
   keywords = {Nerve injury; Cytokines; Neuroinflammation; Sham operation},
   language = {eng},
   issn = {0304-3940},
   journal = {Neuroscience Letters},
   title = {Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve},
   volume = {501},
   year = {2011}
}

TY  - JOUR
ID  - 949872
AU  - Jančálek, Radim - Hradilová Svíženská, Ivana - Klusáková, Ilona - Dubový, Petr
PY  - 2011
TI  - Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve
JF  - Neuroscience Letters
VL  - 501
IS  - 2
SP  - 86-91
EP  - 86-91
PB  - Elsevier Ireland Ltd.
SN  - 03043940
KW  - Nerve injury
KW  - Cytokines
KW  - Neuroinflammation
KW  - Sham operation
N2  - Interleukin-10 prevents transition of a physiological inflammatory reaction to a pathological state that may result in neuropathic pain. We studied bilateral changes of IL-10 in L4–L5 and C7–C8 dorsal root ganglia (DRG) after a chronic constriction injury (CCI) of spinal nerves or the sciatic nerve. Rats were left to survive for 1,3,7 or 14d, sham-operated for 3 or 14 d. IL-10 was detected by immunohistochemical staining and measured using ELISA analysis. Unilateral CCI induced a transient bilateral elevation in IL-10 not only in the homonymous lumbar but also in the heteronymous cervical DRG. Sham operations also induced bilateral elevation of IL-10 in both homonymous and heteronymous DRG. Our experiments revealed that the more proximal is a nerve injury the more rapid is the initial increase and slower the subsequent decrease of IL-10 in DRG. Changes of IL-10 in nonassociated DRG could be related to a general neuroinflammatory reaction of the nervous system to injury and thereby promote potential of the DRG neurons for regenerating their axons following a conditioning lesion.
ER  -

JANČÁLEK, Radim, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ a Petr DUBOVÝ. Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve. \textit{Neuroscience Letters}. Elsevier Ireland Ltd., 2011, roč.~501, č.~2, s.~86-91. ISSN~0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2011.06.052.

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