| JANČÁLEK, Radim, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ a Petr DUBOVÝ. Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve. Neuroscience Letters. Elsevier Ireland Ltd., 2011, roč. 501, č. 2, s. 86-91. ISSN 0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2011.06.052. |
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@article{949872,
author = {Jančálek, Radim and Hradilová Svíženská, Ivana and Klusáková, Ilona and Dubový, Petr},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.neulet.2011.06.052},
keywords = {Nerve injury; Cytokines; Neuroinflammation; Sham operation},
language = {eng},
issn = {0304-3940},
journal = {Neuroscience Letters},
title = {Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve},
volume = {501},
year = {2011}
}
TY - JOUR
ID - 949872
AU - Jančálek, Radim - Hradilová Svíženská, Ivana - Klusáková, Ilona - Dubový, Petr
PY - 2011
TI - Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve
JF - Neuroscience Letters
VL - 501
IS - 2
SP - 86-91
EP - 86-91
PB - Elsevier Ireland Ltd.
SN - 03043940
KW - Nerve injury
KW - Cytokines
KW - Neuroinflammation
KW - Sham operation
N2 - Interleukin-10 prevents transition of a physiological inflammatory reaction to a pathological state that may result in neuropathic pain. We studied bilateral changes of IL-10 in L4–L5 and C7–C8 dorsal root ganglia (DRG) after a chronic constriction injury (CCI) of spinal nerves or the sciatic nerve. Rats were left to survive for 1,3,7 or 14d, sham-operated for 3 or 14 d. IL-10 was detected by immunohistochemical staining and measured using ELISA analysis. Unilateral CCI induced a transient bilateral elevation in IL-10 not only in the homonymous lumbar but also in the heteronymous cervical DRG. Sham operations also induced bilateral elevation of IL-10 in both homonymous and heteronymous DRG. Our experiments revealed that the more proximal is a nerve injury the more rapid is the initial increase and slower the subsequent decrease of IL-10 in DRG. Changes of IL-10 in nonassociated DRG could be related to a general neuroinflammatory reaction of the nervous system to injury and thereby promote potential of the DRG neurons for regenerating their axons following a conditioning lesion.
ER -
JANČÁLEK, Radim, Ivana HRADILOVÁ SVÍŽENSKÁ, Ilona KLUSÁKOVÁ a Petr DUBOVÝ. Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve. \textit{Neuroscience Letters}. Elsevier Ireland Ltd., 2011, roč.~501, č.~2, s.~86-91. ISSN~0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2011.06.052.
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