Plasma HDL-cholesterol and triglyceride levels in familial
hypercholesterolemia: Data from the MedPed CZ database and the
Czech population

J 2011

Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population

SOŠKA, Vladimír, Tomáš FREIBERGER, Renata CIFKOVÁ, Věra LÁNSKÁ, Michal VRABLÍK et. al.

Základní údaje

Originální název

Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population

Autoři

SOŠKA, Vladimír (203 Česká republika, domácí), Tomáš FREIBERGER (203 Česká republika), Renata CIFKOVÁ (203 Česká republika), Věra LÁNSKÁ (203 Česká republika), Michal VRABLÍK (203 Česká republika), Lenka FAJKUSOVÁ (203 Česká republika) a Richard ČEŠKA (203 Česká republika, garant)

Vydání

Clinica Chimica Acta, 2011, 0009-8981

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.535

Kód RIV

RIV/00216224:14740/11:00053069

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.cca.2011.01.017

UT WoS

000291125200019

Klíčová slova anglicky

Familial hypercholesterolemia; HDL-cholesterol; Triglycerides; Familial defective apolipoprotein B-100 (FDB); Czech post-MONICA study

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 4. 2012 08:56, Olga Křížová

Anotace

V originále

The aim of this study was to compare HDL-cholesterol and triglyceride levels in patients with familial hypercholesterolemia (FH) with a representative sample of the Czech population. For the FH group: data of 1728 adult patients with FH (600 males and 1128 females) were taken from the MedPed CR database. The control group were 1995 individuals of the population sample of the Czech post-MONICA study (956 males and 1039 females). Compared with controls, FH males showed higher levels of HDL-cholesterol and triglycerides. After adjustment for age and BMI, the increase in triglycerides remained significant in the subgroup of non-FDB males only. Compared with controls, HDL-cholesterol was lower, while triglycerides were higher in FH females. After adjustment for age and BMI, HDL-cholesterol remained lower in the subgroup of FH females without FDB whereas triglycerides were higher in both female subgroups. A lower HDL-C in the group of FH patients compared with control subjects was demonstrated in FH females without FDB only. Elevated triglyceride levels were found in FH males and females, except for males with FDB.

Návaznosti

MSM0021622415, záměr

Název: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární podstata buněčných a tkáňových regulací

2B08060, projekt VaV

Název: Vývoj diagnostiky a léčby závažných onemocnění srdce a cév pomocí genomických a epigenomických přístupů (Akronym: EPICARD)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vývoj diagnostiky a léčby závažných onemocnění srdce a cév pomocí genomických a epigenomických přístupů

Citovat

SOŠKA, Vladimír, Tomáš FREIBERGER, Renata CIFKOVÁ, Věra LÁNSKÁ, Michal VRABLÍK, Lenka FAJKUSOVÁ a Richard ČEŠKA. Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population. Clinica Chimica Acta. 2011, roč. 412, 11-12, s. 920-924. ISSN 0009-8981. Dostupné z: https://dx.doi.org/10.1016/j.cca.2011.01.017.

@article{949952,
   author = {Soška, Vladimír and Freiberger, Tomáš and Cifková, Renata and Lánská, Věra and Vrablík, Michal and Fajkusová, Lenka and Češka, Richard},
   article_number = {11-12},
   doi = {http://dx.doi.org/10.1016/j.cca.2011.01.017},
   keywords = {Familial hypercholesterolemia; HDL-cholesterol; Triglycerides; Familial defective apolipoprotein B-100 (FDB); Czech post-MONICA study},
   language = {eng},
   issn = {0009-8981},
   journal = {Clinica Chimica Acta},
   title = {Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population},
   volume = {412},
   year = {2011}
}

TY  - JOUR
ID  - 949952
AU  - Soška, Vladimír - Freiberger, Tomáš - Cifková, Renata - Lánská, Věra - Vrablík, Michal - Fajkusová, Lenka - Češka, Richard
PY  - 2011
TI  - Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population
JF  - Clinica Chimica Acta
VL  - 412
IS  - 11-12
SP  - 920-924
EP  - 920-924
SN  - 00098981
KW  - Familial hypercholesterolemia
KW  - HDL-cholesterol
KW  - Triglycerides
KW  - Familial defective apolipoprotein B-100 (FDB)
KW  - Czech post-MONICA study
N2  - The aim of this study was to compare HDL-cholesterol and triglyceride levels in patients with familial hypercholesterolemia (FH) with a representative sample of the Czech population. For the FH group: data of 1728 adult patients with FH (600 males and 1128 females) were taken from the MedPed CR database. The control group were 1995 individuals of the population sample of the Czech post-MONICA study (956 males and 1039 females). Compared with controls, FH males showed higher levels of HDL-cholesterol and triglycerides. After adjustment for age and BMI, the increase in triglycerides remained significant in the subgroup of non-FDB males only. Compared with controls, HDL-cholesterol was lower, while triglycerides were higher in FH females. After adjustment for age and BMI, HDL-cholesterol remained lower in the subgroup of FH females without FDB whereas triglycerides were higher in both female subgroups. A lower HDL-C in the group of FH patients compared with control subjects was demonstrated in FH females without FDB only. Elevated triglyceride levels were found in FH males and females, except for males with FDB.
ER  -

SOŠKA, Vladimír, Tomáš FREIBERGER, Renata CIFKOVÁ, Věra LÁNSKÁ, Michal VRABLÍK, Lenka FAJKUSOVÁ a Richard ČEŠKA. Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: Data from the MedPed CZ database and the Czech population. \textit{Clinica Chimica Acta}. 2011, roč.~412, 11-12, s.~920-924. ISSN~0009-8981. Dostupné z: https://dx.doi.org/10.1016/j.cca.2011.01.017.

Podrobný výpis o publikaci