Expression and characterization of c-Myb in prenatal
odontogenesis

J 2011

Expression and characterization of c-Myb in prenatal odontogenesis

MATALOVÁ, Eva, Marcela BUCHTOVÁ, Abigail S TUCKER, Timothy P BENDER, Eva JANEČKOVÁ et. al.

Základní údaje

Originální název

Expression and characterization of c-Myb in prenatal odontogenesis

Název česky

Exprese a charakterizace c-Myb v prenatální odontogenezi

Autoři

MATALOVÁ, Eva (203 Česká republika, garant, domácí), Marcela BUCHTOVÁ (203 Česká republika, domácí), Abigail S TUCKER (826 Velká Británie a Severní Irsko), Timothy P BENDER (840 Spojené státy), Eva JANEČKOVÁ (203 Česká republika, domácí), Vlasta LUNGOVÁ (203 Česká republika), Simona BALKOVÁ (203 Česká republika, domácí) a Jan ŠMARDA (203 Česká republika, domácí)

Vydání

Development, Growth and Differentiation, USA, WILEY-BLACKWELL, 2011, 0012-1592

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.210

Kód RIV

RIV/00216224:14110/11:00053073

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/j.1440-169X.2011.01287.x

UT WoS

000293902200004

Klíčová slova anglicky

morphogenesis; mouse; Myb; pig; tooth

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 8. 2013 15:47, MDDr. Mgr. Simona Moravcová Balková, Ph.D.

Anotace

V originále

The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. In the minipig, in contrast to the mouse, there was an asymmetrical arrangement of c-Myb positive cells, with a higher presence on the labial side of the tooth germ and dental lamina. A cluster of negative cells was situated in the mesenchyme close to the tooth bud. At later stages, the number of positive cells decreased and these cells were situated in the upper part of the dental papilla in the areas of future cusp formation. The expression of c-Myb in both species was strong in the odontoblasts and ameloblasts at the stage of dentin and enamel production suggesting a possible novel role of c-Myb during tooth mineralization.

Návaznosti

MSM0021622415, záměr

Název: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární podstata buněčných a tkáňových regulací

Citovat

MATALOVÁ, Eva, Marcela BUCHTOVÁ, Abigail S TUCKER, Timothy P BENDER, Eva JANEČKOVÁ, Vlasta LUNGOVÁ, Simona BALKOVÁ a Jan ŠMARDA. Expression and characterization of c-Myb in prenatal odontogenesis. Development, Growth and Differentiation. USA: WILEY-BLACKWELL, 2011, roč. 53, č. 6, s. 793-803. ISSN 0012-1592. Dostupné z: https://dx.doi.org/10.1111/j.1440-169X.2011.01287.x.

@article{949958,
   author = {Matalová, Eva and Buchtová, Marcela and Tucker, Abigail S and Bender, Timothy P and Janečková, Eva and Lungová, Vlasta and Balková, Simona and Šmarda, Jan},
   article_location = {USA},
   article_number = {6},
   doi = {http://dx.doi.org/10.1111/j.1440-169X.2011.01287.x},
   keywords = {morphogenesis; mouse; Myb; pig; tooth},
   language = {eng},
   issn = {0012-1592},
   journal = {Development, Growth and Differentiation},
   title = {Expression and characterization of c-Myb in prenatal odontogenesis},
   volume = {53},
   year = {2011}
}

TY  - JOUR
ID  - 949958
AU  - Matalová, Eva - Buchtová, Marcela - Tucker, Abigail S - Bender, Timothy P - Janečková, Eva - Lungová, Vlasta - Balková, Simona - Šmarda, Jan
PY  - 2011
TI  - Expression and characterization of c-Myb in prenatal odontogenesis
JF  - Development, Growth and Differentiation
VL  - 53
IS  - 6
SP  - 793-803
EP  - 793-803
PB  - WILEY-BLACKWELL
SN  - 00121592
KW  - morphogenesis
KW  - mouse
KW  - Myb
KW  - pig
KW  - tooth
N2  - The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. In the minipig, in contrast to the mouse, there was an asymmetrical arrangement of c-Myb positive cells, with a higher presence on the labial side of the tooth germ and dental lamina. A cluster of negative cells was situated in the mesenchyme close to the tooth bud. At later stages, the number of positive cells decreased and these cells were situated in the upper part of the dental papilla in the areas of future cusp formation. The expression of c-Myb in both species was strong in the odontoblasts and ameloblasts at the stage of dentin and enamel production suggesting a possible novel role of c-Myb during tooth mineralization.
ER  -

MATALOVÁ, Eva, Marcela BUCHTOVÁ, Abigail S TUCKER, Timothy P BENDER, Eva JANEČKOVÁ, Vlasta LUNGOVÁ, Simona BALKOVÁ a Jan ŠMARDA. Expression and characterization of c-Myb in prenatal odontogenesis. \textit{Development, Growth and Differentiation}. USA: WILEY-BLACKWELL, 2011, roč.~53, č.~6, s.~793-803. ISSN~0012-1592. Dostupné z: https://dx.doi.org/10.1111/j.1440-169X.2011.01287.x.

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