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@article{949985,
author = {Meluzín, Jaroslav and Sitar, Jan and Křístek, Jan and Prosecký, Robert and Pešl, Martin and Podroužková, Helena and Soška, Vladimír and Panovský, Roman and Dušek, Ladislav},
article_number = {8},
doi = {http://dx.doi.org/10.1093/ejechocard/jer082},
keywords = {Exercise echocardiography; Diastolic heart failure},
language = {eng},
issn = {1525-2167},
journal = {European Journal of Echocardiography},
title = {The role of exercise echocardiography in the diagnostics of heart failure with normal left ventricular ejection fraction},
volume = {12},
year = {2011}
}
TY - JOUR
ID - 949985
AU - Meluzín, Jaroslav - Sitar, Jan - Křístek, Jan - Prosecký, Robert - Pešl, Martin - Podroužková, Helena - Soška, Vladimír - Panovský, Roman - Dušek, Ladislav
PY - 2011
TI - The role of exercise echocardiography in the diagnostics of heart failure with normal left ventricular ejection fraction
JF - European Journal of Echocardiography
VL - 12
IS - 8
SP - 591–602
EP - 591–602
SN - 15252167
KW - Exercise echocardiography
KW - Diastolic heart failure
N2 - Few data are available on the exercise-induced abnormalities of myocardial function in patients with exertional dyspnoea and normal left ventricular ejection fraction (LV EF). The main aims of this study were to determine the prevalence of isolated exercise-induced heart failure with normal ejection fraction (HFNEF) and to assess whether disturbances in LV or right ventricular longitudinal systolic function are associated with the diagnosis of HFNEF. Eighty-four patients with exertional dyspnoea and normal LV EF and 14 healthy controls underwent spirometry, NT-proBNP plasma analysis, and exercise echocardiography. Doppler LV inflow and tissue mitral and tricuspid annular velocities were analysed at rest and immediately after the termination of exercise. Of the 30 patients with the evidence of HFNEF, 6 (20%) patients had only isolated exercise-induced HFNEF. When compared with the remaining patients, those with HFNEF had a significantly lower resting and exercise peak mitral annular systolic velocity (Sa) and the mitral annular velocity during atrial contraction, lower exercise peak mitral annular velocity at early diastole, and lower exercise peak systolic velocity of tricuspid annular motion. The multivariate logistic regression analysis including both parameters standardly defining HFNEF and the new Doppler variables potentially associated with the diagnosis of HFNEF revealed that NT-proBNP, LV mass index, left atrial volume index, and Sa significantly and independently predict the diagnosis of HFNEF. A significant proportion of patients require exercise to diagnose HFNEF. Sa appears to be a significant independent predictor of HFNEF, which may increase the diagnostic value of models utilizing the variables recommended by the European Society of Cardiology guidelines.
ER -
MELUZÍN, Jaroslav, Jan SITAR, Jan KŘÍSTEK, Robert PROSECKÝ, Martin PEŠL, Helena PODROUŽKOVÁ, Vladimír SOŠKA, Roman PANOVSKÝ and Ladislav DUŠEK. The role of exercise echocardiography in the diagnostics of heart failure with normal left ventricular ejection fraction. \textit{European Journal of Echocardiography}. 2011, vol.~12, No~8, p.~591–602. ISSN~1525-2167. Available from: https://dx.doi.org/10.1093/ejechocard/jer082.
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