J 2011

The role of exercise echocardiography in the diagnostics of heart failure with normal left ventricular ejection fraction

MELUZÍN, Jaroslav, Jan SITAR, Jan KŘÍSTEK, Robert PROSECKÝ, Martin PEŠL et. al.

Basic information

Original name

The role of exercise echocardiography in the diagnostics of heart failure with normal left ventricular ejection fraction

Authors

MELUZÍN, Jaroslav (203 Czech Republic, guarantor, belonging to the institution), Jan SITAR (203 Czech Republic), Jan KŘÍSTEK (203 Czech Republic, belonging to the institution), Robert PROSECKÝ (203 Czech Republic, belonging to the institution), Martin PEŠL (203 Czech Republic, belonging to the institution), Helena PODROUŽKOVÁ (203 Czech Republic, belonging to the institution), Vladimír SOŠKA (203 Czech Republic, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, belonging to the institution) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution)

Edition

European Journal of Echocardiography, 2011, 1525-2167

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.317

RIV identification code

RIV/00216224:14110/11:00053080

Organization unit

Faculty of Medicine

DOI

UT WoS

000294861700005

Keywords in English

Exercise echocardiography; Diastolic heart failure

Tags

International impact
Změněno: 23/3/2012 13:38, Mgr. Michal Petr

Abstract

V originále

Few data are available on the exercise-induced abnormalities of myocardial function in patients with exertional dyspnoea and normal left ventricular ejection fraction (LV EF). The main aims of this study were to determine the prevalence of isolated exercise-induced heart failure with normal ejection fraction (HFNEF) and to assess whether disturbances in LV or right ventricular longitudinal systolic function are associated with the diagnosis of HFNEF. Eighty-four patients with exertional dyspnoea and normal LV EF and 14 healthy controls underwent spirometry, NT-proBNP plasma analysis, and exercise echocardiography. Doppler LV inflow and tissue mitral and tricuspid annular velocities were analysed at rest and immediately after the termination of exercise. Of the 30 patients with the evidence of HFNEF, 6 (20%) patients had only isolated exercise-induced HFNEF. When compared with the remaining patients, those with HFNEF had a significantly lower resting and exercise peak mitral annular systolic velocity (Sa) and the mitral annular velocity during atrial contraction, lower exercise peak mitral annular velocity at early diastole, and lower exercise peak systolic velocity of tricuspid annular motion. The multivariate logistic regression analysis including both parameters standardly defining HFNEF and the new Doppler variables potentially associated with the diagnosis of HFNEF revealed that NT-proBNP, LV mass index, left atrial volume index, and Sa significantly and independently predict the diagnosis of HFNEF. A significant proportion of patients require exercise to diagnose HFNEF. Sa appears to be a significant independent predictor of HFNEF, which may increase the diagnostic value of models utilizing the variables recommended by the European Society of Cardiology guidelines.

Links

MSM0021622402, plan (intention)
Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases