Inhibition of cyclooxygenase-2 promotes the stimulatory action
of adenosine A3 receptor agonist on hematopoiesis in
sublethally y-irradiated mice

J 2011

Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ; Lenka WEITEROVÁ et. al.

Basic information

Original name

Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice

Authors

HOFER, Michal (203 Czech Republic, guarantor); Milan POSPÍŠIL (203 Czech Republic); Ladislav DUŠEK (203 Czech Republic, belonging to the institution); Zuzana HOFEROVÁ (203 Czech Republic) and Lenka WEITEROVÁ (203 Czech Republic)

Edition

Biomedicine & Pharmacotherapy, 2011, 0753-3322

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

10610 Biophysics

Country of publisher

Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 2.000

RIV identification code

RIV/00216224:14110/11:00049995

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.biopha.2011.04.033

UT WoS

000296961900006

Keywords in English

Hematopoiesis; COX-2 inhibitor; Adenosine A3 receptor agonist

Abstract

V originále

Mouse hematopoiesis, suppressed by a sublethal dose of ionizing radiation, was the target for combined therapy with a cyclooxygenase-2 (COX-2) inhibitor meloxicam and an adenosine A3 receptor agonist IB-MECA. The drugs were administered in an early postirradiation treatment regimen: meloxicam was given in a single dose 1 hour after irradiation, IB-MECA in two doses 24 and 48 hours after irradiation. Treatment-induced changes in several compartments of hematopoietic progenitor and precursor cells of the bone marrow were evaluated on day 3 after irradiation. Values of hematopoietic progenitor cells for granulocytes/macrophages and erythrocytes (GM-CFC and BFU-E, respectively), as well as those of proliferative granulocytic cells were found to be significantly higher in the mice treated with the drug combination in comparison to irradiated controls and attained the highest increase factors of 1.6, 1.6, and 2.6, respectively. The study emphasizes the significance of the combined treatment of suppressed hematopoiesis with more agents. Mechanisms of the action of the individual compounds of the studied drug combination and of their joint operation are discussed.

Links

GA305/08/0158, research and development project

Name: Aktivace adenosinových receptorů kombinovaná s inhibicí cyklooxygenázy v modulaci zářením vyvolaného poškození kostní dřeně

Investor: Czech Science Foundation, Activation of adenosine receptors combined with cyclooxygenase inhibition in modulation of radiation-induced myelosuppression

Cite

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ and Lenka WEITEROVÁ. Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice. Biomedicine & Pharmacotherapy. 2011, vol. 65, No 6, p. 427-431. ISSN 0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2011.04.033.

@article{950786,
   author = {Hofer, Michal and Pospíšil, Milan and Dušek, Ladislav and Hoferová, Zuzana and Weiterová, Lenka},
   article_number = {6},
   doi = {http://dx.doi.org/10.1016/j.biopha.2011.04.033},
   keywords = {Hematopoiesis; COX-2 inhibitor; Adenosine A3 receptor agonist},
   language = {eng},
   issn = {0753-3322},
   journal = {Biomedicine & Pharmacotherapy},
   title = {Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice},
   url = {http://www.sciencedirect.com/science/article/pii/S0753332211000758},
   volume = {65},
   year = {2011}
}

TY  - JOUR
ID  - 950786
AU  - Hofer, Michal - Pospíšil, Milan - Dušek, Ladislav - Hoferová, Zuzana - Weiterová, Lenka
PY  - 2011
TI  - Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice
JF  - Biomedicine & Pharmacotherapy
VL  - 65
IS  - 6
SP  - 427-431
EP  - 427-431
SN  - 07533322
KW  - Hematopoiesis
KW  - COX-2 inhibitor
KW  - Adenosine A3 receptor agonist
UR  - http://www.sciencedirect.com/science/article/pii/S0753332211000758
N2  - Mouse hematopoiesis, suppressed by a sublethal dose of ionizing radiation, was the target for combined therapy with a cyclooxygenase-2 (COX-2) inhibitor meloxicam and an adenosine A3 receptor agonist IB-MECA. The drugs were administered in an early postirradiation treatment regimen: meloxicam was given in a single dose 1 hour after irradiation, IB-MECA in two doses 24 and 48 hours after irradiation. Treatment-induced changes in several compartments of hematopoietic progenitor and precursor cells of the bone marrow were evaluated on day 3 after irradiation. Values of hematopoietic progenitor cells for granulocytes/macrophages and erythrocytes (GM-CFC and BFU-E, respectively), as well as those of proliferative granulocytic cells were found to be significantly higher in the mice treated with the drug combination in comparison to irradiated controls and attained the highest increase factors of 1.6, 1.6, and 2.6, respectively. The study emphasizes the significance of the combined treatment of suppressed hematopoiesis with more agents. Mechanisms of the action of the individual compounds of the studied drug combination and of their joint operation are discussed.
ER  -

HOFER, Michal; Milan POSPÍŠIL; Ladislav DUŠEK; Zuzana HOFEROVÁ and Lenka WEITEROVÁ. Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice. \textit{Biomedicine \&{} Pharmacotherapy}. 2011, vol.~65, No~6, p.~427-431. ISSN~0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2011.04.033.

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