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@article{950806,
author = {Bareš, Martin and Lungu, Ovidiu V. and Liu, Tao and Waechter, Tobias and Gomez, Christopher M. and Ashe, James},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s12311-010-0237-y},
keywords = {Cerebellum; Basal ganglia; Motor timing; Functional imaging},
language = {eng},
issn = {1473-4222},
journal = {Cerebellum},
title = {The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia},
volume = {10},
year = {2011}
}
TY - JOUR
ID - 950806
AU - Bareš, Martin - Lungu, Ovidiu V. - Liu, Tao - Waechter, Tobias - Gomez, Christopher M. - Ashe, James
PY - 2011
TI - The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia
JF - Cerebellum
VL - 10
IS - 2
SP - 233-244
EP - 233-244
SN - 14734222
KW - Cerebellum
KW - Basal ganglia
KW - Motor timing
KW - Functional imaging
N2 - The neural mechanisms involved in motor timing are subcortical, involving mainly cerebellum and basal ganglia. However, the role played by these structures in predictive motor timing is not well understood. Unlike motor timing, which is often tested using rhythm production tasks, predictive motor timing requires visuo-motor coordination in anticipation of a future event, and it is evident in behaviors such as catching a ball or shooting a moving target. We examined the role of the cerebellum and striatum in predictive motor timing in a target interception task in healthy (n = 12) individuals and in subjects (n = 9) with spinocerebellar ataxia types 6 and 8. The performance of the healthy subjects was better than that of the spinocerebellar ataxia. Successful performance in both groups was associated with increased activity in the cerebellum (right dentate nucleus, left uvula (lobule V), and lobule VI), thalamus, and in several cortical areas. The superior performance in the controls was related to activation in thalamus, putamen (lentiform nucleus) and cerebellum (right dentate nucleus and culmen-lobule IV), which were not activated either in the spinocerebellar subjects or within a subgroup of controls who performed poorly. Both the cerebellum and the basal ganglia are necessary for the predictive motor timing. The degeneration of the cerebellum associated with spinocerebellar types 6 and 8 appears to lead to quantitative rather than qualitative deficits in temporal processing. The lack of any areas with greater activity in the spinocerebellar group than in controls suggests that limited functional reorganization occurs in this condition.
ER -
BAREŠ, Martin, Ovidiu V. LUNGU, Tao LIU, Tobias WAECHTER, Christopher M. GOMEZ a James ASHE. The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia. \textit{Cerebellum}. 2011, roč.~10, č.~2, s.~233-244. ISSN~1473-4222. Dostupné z: https://dx.doi.org/10.1007/s12311-010-0237-y.
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