BALÁŽ, Marek, Martina BOČKOVÁ, Irena REKTOROVÁ and Ivan REKTOR. Involvement of the subthalamic nucleus in cognitive functions — A concept. Journal of the Neurological Sciences. 2011, vol. 310, 1-2, p. 96-99. ISSN 0022-510X. Available from: https://dx.doi.org/10.1016/j.jns.2011.07.016.
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Basic information
Original name Involvement of the subthalamic nucleus in cognitive functions — A concept
Authors BALÁŽ, Marek (703 Slovakia, guarantor, belonging to the institution), Martina BOČKOVÁ (203 Czech Republic, belonging to the institution), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, belonging to the institution).
Edition Journal of the Neurological Sciences, 2011, 0022-510X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.353
RIV identification code RIV/00216224:14110/11:00053200
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.jns.2011.07.016
UT WoS 000296927500024
Keywords in English Subthalamic nucleus; Basal ganglia; Cognitive functions; Deep brain stimulation; Hyperdirect pathway
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 23/3/2012 13:43.
Abstract
The involvement of the subthalamic nucleus (STN) in a broad spectrum of various non-motor functions – attention, executive functions, verbal learning and memory, verbal abstract reasoning, conflict resolution, and emotions – has been reported. The STN has an anatomically central position within the basal ganglia(BG)-thalamocortical motor, associative and limbic circuits. The STN might interfere with non-motor functions as an indirect modulator rather than a regulator. Mechanisms modulating the motor and non-motor functions might differ. The STN has been implicated in control of non-motor behaviors via the tuning of specific circuits depending on the task. The STN might modulate selected non-motor functions via contextual modulation of certain cortical areas. Based on intracerebral recordings, we proposed that the non-motor activities in the BG are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits. These findings support the hypothesis of a cortico-STN bypass of the BG-thalamocortical circuitry under some circumstances. The exact role of the STN and the BG in non-motor functions remains an important and interesting challenge for future research.
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