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@article{950971, author = {Baláž, Marek and Bočková, Martina and Rektorová, Irena and Rektor, Ivan}, article_number = {1-2}, doi = {http://dx.doi.org/10.1016/j.jns.2011.07.016}, keywords = {Subthalamic nucleus; Basal ganglia; Cognitive functions; Deep brain stimulation; Hyperdirect pathway}, language = {eng}, issn = {0022-510X}, journal = {Journal of the Neurological Sciences}, note = {7th International Congress on Mental Dysfunction and other Non-Motor Features in Parkinsons Disease and Related Disorders, Barcelona, DEC 09-12, 2010}, title = {Involvement of the subthalamic nucleus in cognitive functions — A concept}, volume = {310}, year = {2011} }
TY - JOUR ID - 950971 AU - Baláž, Marek - Bočková, Martina - Rektorová, Irena - Rektor, Ivan PY - 2011 TI - Involvement of the subthalamic nucleus in cognitive functions — A concept JF - Journal of the Neurological Sciences VL - 310 IS - 1-2 SP - 96-99 EP - 96-99 SN - 0022510X N1 - 7th International Congress on Mental Dysfunction and other Non-Motor Features in Parkinsons Disease and Related Disorders, Barcelona, DEC 09-12, 2010 KW - Subthalamic nucleus KW - Basal ganglia KW - Cognitive functions KW - Deep brain stimulation KW - Hyperdirect pathway N2 - The involvement of the subthalamic nucleus (STN) in a broad spectrum of various non-motor functions – attention, executive functions, verbal learning and memory, verbal abstract reasoning, conflict resolution, and emotions – has been reported. The STN has an anatomically central position within the basal ganglia(BG)-thalamocortical motor, associative and limbic circuits. The STN might interfere with non-motor functions as an indirect modulator rather than a regulator. Mechanisms modulating the motor and non-motor functions might differ. The STN has been implicated in control of non-motor behaviors via the tuning of specific circuits depending on the task. The STN might modulate selected non-motor functions via contextual modulation of certain cortical areas. Based on intracerebral recordings, we proposed that the non-motor activities in the BG are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits. These findings support the hypothesis of a cortico-STN bypass of the BG-thalamocortical circuitry under some circumstances. The exact role of the STN and the BG in non-motor functions remains an important and interesting challenge for future research. ER -
BALÁŽ, Marek, Martina BOČKOVÁ, Irena REKTOROVÁ a Ivan REKTOR. Involvement of the subthalamic nucleus in cognitive functions — A concept. \textit{Journal of the Neurological Sciences}. 2011, roč.~310, 1-2, s.~96-99. ISSN~0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2011.07.016.
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