Involvement of the subthalamic nucleus in cognitive functions —
A concept

J 2011

Involvement of the subthalamic nucleus in cognitive functions — A concept

BALÁŽ, Marek, Martina BOČKOVÁ, Irena REKTOROVÁ a Ivan REKTOR

Základní údaje

Originální název

Involvement of the subthalamic nucleus in cognitive functions — A concept

Autoři

BALÁŽ, Marek (703 Slovensko, garant, domácí), Martina BOČKOVÁ (203 Česká republika, domácí), Irena REKTOROVÁ (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, domácí)

Vydání

Journal of the Neurological Sciences, 2011, 0022-510X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.353

Kód RIV

RIV/00216224:14110/11:00053200

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jns.2011.07.016

UT WoS

000296927500024

Klíčová slova anglicky

Subthalamic nucleus; Basal ganglia; Cognitive functions; Deep brain stimulation; Hyperdirect pathway

Příznaky

Mezinárodní význam

Změněno: 23. 3. 2012 13:43, Mgr. Michal Petr

Anotace

V originále

The involvement of the subthalamic nucleus (STN) in a broad spectrum of various non-motor functions – attention, executive functions, verbal learning and memory, verbal abstract reasoning, conflict resolution, and emotions – has been reported. The STN has an anatomically central position within the basal ganglia(BG)-thalamocortical motor, associative and limbic circuits. The STN might interfere with non-motor functions as an indirect modulator rather than a regulator. Mechanisms modulating the motor and non-motor functions might differ. The STN has been implicated in control of non-motor behaviors via the tuning of specific circuits depending on the task. The STN might modulate selected non-motor functions via contextual modulation of certain cortical areas. Based on intracerebral recordings, we proposed that the non-motor activities in the BG are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits. These findings support the hypothesis of a cortico-STN bypass of the BG-thalamocortical circuitry under some circumstances. The exact role of the STN and the BG in non-motor functions remains an important and interesting challenge for future research.

Citovat

BALÁŽ, Marek, Martina BOČKOVÁ, Irena REKTOROVÁ a Ivan REKTOR. Involvement of the subthalamic nucleus in cognitive functions — A concept. Journal of the Neurological Sciences. 2011, roč. 310, 1-2, s. 96-99. ISSN 0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2011.07.016.

@article{950971,
   author = {Baláž, Marek and Bočková, Martina and Rektorová, Irena and Rektor, Ivan},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.jns.2011.07.016},
   keywords = {Subthalamic nucleus; Basal ganglia; Cognitive functions; Deep brain stimulation; Hyperdirect pathway},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the Neurological Sciences},
   note = {7th International Congress on Mental Dysfunction and other Non-Motor Features in Parkinsons Disease and Related Disorders, Barcelona, DEC 09-12, 2010},
   title = {Involvement of the subthalamic nucleus in cognitive functions — A concept},
   volume = {310},
   year = {2011}
}

TY  - JOUR
ID  - 950971
AU  - Baláž, Marek - Bočková, Martina - Rektorová, Irena - Rektor, Ivan
PY  - 2011
TI  - Involvement of the subthalamic nucleus in cognitive functions — A concept
JF  - Journal of the Neurological Sciences
VL  - 310
IS  - 1-2
SP  - 96-99
EP  - 96-99
SN  - 0022510X
N1  - 7th International Congress on Mental Dysfunction and other Non-Motor Features in Parkinsons Disease and Related Disorders, Barcelona, DEC 09-12, 2010
KW  - Subthalamic nucleus
KW  - Basal ganglia
KW  - Cognitive functions
KW  - Deep brain stimulation
KW  - Hyperdirect pathway
N2  - The involvement of the subthalamic nucleus (STN) in a broad spectrum of various non-motor functions – attention, executive functions, verbal learning and memory, verbal abstract reasoning, conflict resolution, and emotions – has been reported. The STN has an anatomically central position within the basal ganglia(BG)-thalamocortical motor, associative and limbic circuits. The STN might interfere with non-motor functions as an indirect modulator rather than a regulator. Mechanisms modulating the motor and non-motor functions might differ. The STN has been implicated in control of non-motor behaviors via the tuning of specific circuits depending on the task. The STN might modulate selected non-motor functions via contextual modulation of certain cortical areas. Based on intracerebral recordings, we proposed that the non-motor activities in the BG are organized in some way other than the well-known organization of the cortico-BG-thalamocortical circuits. These findings support the hypothesis of a cortico-STN bypass of the BG-thalamocortical circuitry under some circumstances. The exact role of the STN and the BG in non-motor functions remains an important and interesting challenge for future research.
ER  -

BALÁŽ, Marek, Martina BOČKOVÁ, Irena REKTOROVÁ a Ivan REKTOR. Involvement of the subthalamic nucleus in cognitive functions — A concept. \textit{Journal of the Neurological Sciences}. 2011, roč.~310, 1-2, s.~96-99. ISSN~0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2011.07.016.

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