J 2011

Association of aneuploidy category with centrosome amplification in multiple myeloma

KRYUKOV, Fedor; Elena Vladimirovna DEMENTYEVA; Jan SMETANA; Sabina ŠEVČÍKOVÁ; Petr KUGLÍK et. al.

Basic information

Original name

Association of aneuploidy category with centrosome amplification in multiple myeloma

Authors

KRYUKOV, Fedor (643 Russian Federation, guarantor, belonging to the institution); Elena Vladimirovna DEMENTYEVA (643 Russian Federation, belonging to the institution); Jan SMETANA (203 Czech Republic, belonging to the institution); Sabina ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution); Petr KUGLÍK (203 Czech Republic, belonging to the institution) and Roman HÁJEK (203 Czech Republic, belonging to the institution)

Edition

Leukemia & Lymphoma, 2011, 1042-8194

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 2.580

RIV identification code

RIV/00216224:14110/11:00050008

Organization unit

Faculty of Medicine

DOI

UT WoS

000295176800030

Keywords in English

multiple myeloma; centrosome amplification; plasma cell; B-cell; hyperdiploid

Tags

International impact
Changed: 11/4/2012 16:09, Mgr. Michal Petr

Abstract

In the original language

Multiple myeloma is a lymphoproliferative disease characterized by clonal expansion of neoplastic plasma cells (PCs) within the bone marrow. Although PCs are recognized as fully malignant cells, the exact developmental stage at which malignant transformation occurs is still unknown. Since centrosome abnormalities constitute one of the most important mechanisms implicated in chromosomal instability in cancer, the aim of this study was to investigate a possible association of centrosome amplification in populations of B-cell lineage with specific chromosome aberrations and aneuploidy categories occurring in MM. For this purpose, a total of 140 patients with MM were included in the study. In our study, we showed a correlation between centrosome amplification in B cells and hyperdiploidy in plasma cells. This raises the suspicion of a possible impact of abnormal B cells in myeloma cell development.

Links

GAP304/10/1395, research and development project
Name: Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií
Investor: Czech Science Foundation
LC06027, research and development project
Name: Univerzitní výzkumné centrum - Česká myelomová skupina (Acronym: LC MGUS)
Investor: Ministry of Education, Youth and Sports of the CR, University Research Centre - Czech Myeloma Group
MSM0021622434, plan (intention)
Name: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií
Investor: Ministry of Education, Youth and Sports of the CR, From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
MUNI/A/1012/2009, interní kód MU
Name: Optimalizace diagnostiky a terapie maligních chorob a komplikací, které tyto maligní nemoci provázejí, s využitím nových molekulárně biologických metod.
Investor: Masaryk University, Category A
NS10207, research and development project
Name: Úloha abnormalit chromozómu 1 a kaskády NF-kappaB v patogenezi mnohočetného myelomu
Investor: Ministry of Health of the CR
NS10406, research and development project
Name: Vytvoření prognostického panelu u pacientů s monoklonální gamapatií nejasného významu s cílem zabránění transformace v maligní onemocnění.
Investor: Ministry of Health of the CR
NT11154, research and development project
Name: Úloha mitotické disrupce v B lymfocytech u mnohočetném myelomu
Investor: Ministry of Health of the CR