ŠERÝ, Omar, František ŠŤASTNÝ, Petr ZVOLSKÝ, Zuzana HLINOMAZOVÁ a Vladimír BALCAR. Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients. Neuroscience Letters. Ireland: Elsevier, 2011, roč. 499, č. 3, s. 154 - 157. ISSN 0304-3940. |
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@article{951162, author = {Šerý, Omar and Šťastný, František and Zvolský, Petr and Hlinomazová, Zuzana and Balcar, Vladimír}, article_location = {Ireland}, article_number = {3}, keywords = {Glutamate; GABA; Retina; BDNF; Alcohol; Genetics of alcoholism}, language = {eng}, issn = {0304-3940}, journal = {Neuroscience Letters}, title = {Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients}, volume = {499}, year = {2011} }
TY - JOUR ID - 951162 AU - Šerý, Omar - Šťastný, František - Zvolský, Petr - Hlinomazová, Zuzana - Balcar, Vladimír PY - 2011 TI - Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients JF - Neuroscience Letters VL - 499 IS - 3 SP - 154 - 157 EP - 154 - 157 PB - Elsevier SN - 03043940 KW - Glutamate KW - GABA KW - Retina KW - BDNF KW - Alcohol KW - Genetics of alcoholism N2 - The BDNF polymorphism Va166Met (rs6265) has been studied in the context of etiology of mental diseases including alcoholism. Alcoholism - a complex disorder known to be linked to several genes - has multiple manifestations, including sensory deficits such as those affecting vision. In the present study we examined a relationship between the Va166Met polymorphism, alcohol dependence and colour vision deficiency (CVD) in 167 alcohol-dependent men and 289 control male subjects. Statistical analysis revealed that almost half (about 48%) of the alcohol dependent men had a CVD. In addition we found that CVD was significantly associated (P = 0.005) with the Va166Met polymorphism. The A allele containing 66Met promotes BDNF expression and this may protect humans against CVD induced by long-term excessive alcohol intake. ER -
ŠERÝ, Omar, František ŠŤASTNÝ, Petr ZVOLSKÝ, Zuzana HLINOMAZOVÁ a Vladimír BALCAR. Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients. \textit{Neuroscience Letters}. Ireland: Elsevier, 2011, roč.~499, č.~3, s.~154 - 157. ISSN~0304-3940.
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