HOSÁK, Ladislav, Omar ŠERÝ, Martin BERÁNEK and Martin ALDA. Lack of association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2011, vol. 32, No 4, p. 469 - 474. ISSN 0172-780X.
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Basic information
Original name Lack of association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence
Name in Czech Nenalezený vztah mezi polymorfizmem Val158Met genu pro COMT a závislostí na metamfetaminu
Authors HOSÁK, Ladislav (203 Czech Republic, guarantor), Omar ŠERÝ (203 Czech Republic, belonging to the institution), Martin BERÁNEK (203 Czech Republic) and Martin ALDA (124 Canada).
Edition Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2011, 0172-780X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Sweden
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.296
RIV identification code RIV/00216224:14310/11:00056982
Organization unit Faculty of Science
UT WoS 000295440000019
Keywords (in Czech) asociační studie; psychotická porucha; závislost na metamfetaminu; COMT
Keywords in English methamphetamine dependence; Val158Met catechol-O-methyltransferase polymorphism; population-based genetic association study; family-based genetic association study; psychotic disorder
Tags AKR, rivok
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Omar Šerý, Ph.D., učo 18120. Changed: 9/4/2012 20:11.
Abstract
We did not find any significant association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence using the population-based or family-based design (p=0.41–0.66; Chi-Square Test or UNPHASED program, Version 3.1.4, respectively). We found a trend toward a statistically significant difference between the Val allele carriers and Met/Met homozygotes in the frequence of psychotic symptoms induced by methamphetamine (more frequent in Val carriers; p=0.062; Chi-Square Test).
Abstract (in Czech)
V naší práci jsme se pokusili zjistit vztah mezi polymorfizmem genu pro COMT a závislostí na metamfetaminu. Neobjevili jsme vztah mezi polymorfizmem genu pro COMT a závislostí na metamfetaminu na souboru 123 osob závislých na metamfetaminu a 400 kontrolních osob.
Links
NF5991, research and development projectName: Genetika závislostí: zjišťování vztahu polymorfizmů kandidátních genů k alkoholizmu
Investor: Ministry of Health of the CR, Genetic study of alcohol dependence : detection of the association between candidate gene polymorphisms and alcoholism.
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