Acetylation-dependent nuclear arrangement and recruitment of
BMI1 protein to UV-damaged chromatin

J 2012

Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin

ŠUSTÁČKOVÁ, Gabriela, Stanislav KOZUBEK, Lenka STIXOVÁ, Soňa LEGARTOVÁ, Pavel MATULA et. al.

Základní údaje

Originální název

Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin

Autoři

ŠUSTÁČKOVÁ, Gabriela (203 Česká republika), Stanislav KOZUBEK (203 Česká republika), Lenka STIXOVÁ (203 Česká republika), Soňa LEGARTOVÁ (703 Slovensko), Pavel MATULA (203 Česká republika, garant, domácí), Darya Yurevna ORLOVA (643 Rusko) a Eva BÁRTOVÁ (203 Česká republika)

Vydání

Journal of cellular physiology, United States, Wiley-Liss, 2012, 0021-9541

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.218

Kód RIV

RIV/00216224:14330/12:00059085

Organizační jednotka

Fakulta informatiky

DOI

http://dx.doi.org/10.1002/jcp.22912

UT WoS

000299373900008

Klíčová slova anglicky

Polycomb body BMI1 protein arrangement confocal microscopy

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 4. 2013 16:35, doc. RNDr. Pavel Matula, Ph.D.

Anotace

V originále

Polycomb group (PcG) proteins, organized into Polycomb bodies, are important regulatory components of epigenetic processes involved in the heritable transcriptional repression of target genes. Here, we asked whether acetylation can influence the nuclear arrangement and function of the BMI1 protein, a core component of the Polycomb group complex, PRC1. We used time-lapse confocal microscopy, micro-irradiation by UV laser (355 nm) and GFP technology to study the dynamics and function of the BMI1 protein. Our data indicate that the dynamics of recognition of UV-damaged chromatin, and the nuclear arrangement of BMI1 protein can be influenced by acetylation and occur as an early event prior to the recruitment of HPb to UV-irradiated chromatin.

Návaznosti

LC535, projekt VaV

Název: Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii

Citovat

ŠUSTÁČKOVÁ, Gabriela, Stanislav KOZUBEK, Lenka STIXOVÁ, Soňa LEGARTOVÁ, Pavel MATULA, Darya Yurevna ORLOVA a Eva BÁRTOVÁ. Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. Journal of cellular physiology. United States: Wiley-Liss, 2012, roč. 227, č. 5, s. 1838-1850. ISSN 0021-9541. Dostupné z: https://dx.doi.org/10.1002/jcp.22912.

@article{952094,
   author = {Šustáčková, Gabriela and Kozubek, Stanislav and Stixová, Lenka and Legartová, Soňa and Matula, Pavel and Orlova, Darya Yurevna and Bártová, Eva},
   article_location = {United States},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/jcp.22912},
   keywords = {Polycomb body BMI1 protein arrangement confocal microscopy},
   language = {eng},
   issn = {0021-9541},
   journal = {Journal of cellular physiology},
   title = {Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/jcp.22912/suppinfo},
   volume = {227},
   year = {2012}
}

TY  - JOUR
ID  - 952094
AU  - Šustáčková, Gabriela - Kozubek, Stanislav - Stixová, Lenka - Legartová, Soňa - Matula, Pavel - Orlova, Darya Yurevna - Bártová, Eva
PY  - 2012
TI  - Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin
JF  - Journal of cellular physiology
VL  - 227
IS  - 5
SP  - 1838-1850
EP  - 1838-1850
PB  - Wiley-Liss
SN  - 00219541
KW  - Polycomb body BMI1 protein arrangement confocal microscopy
UR  - http://onlinelibrary.wiley.com/doi/10.1002/jcp.22912/suppinfo
L2  - http://onlinelibrary.wiley.com/doi/10.1002/jcp.22912/suppinfo
N2  - Polycomb group (PcG) proteins, organized into Polycomb bodies, are important regulatory components of epigenetic processes involved in the heritable transcriptional repression of target genes. Here, we asked whether acetylation can influence the nuclear arrangement and function of the BMI1 protein, a core component of the Polycomb group complex, PRC1. We used time-lapse confocal microscopy, micro-irradiation by UV laser (355 nm) and GFP technology to study the dynamics and function of the BMI1 protein. Our data indicate that the dynamics of recognition of UV-damaged chromatin, and the nuclear arrangement of BMI1 protein can be influenced by acetylation and occur as an early event prior to the recruitment of HPb to UV-irradiated chromatin.
ER  -

ŠUSTÁČKOVÁ, Gabriela, Stanislav KOZUBEK, Lenka STIXOVÁ, Soňa LEGARTOVÁ, Pavel MATULA, Darya Yurevna ORLOVA a Eva BÁRTOVÁ. Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. \textit{Journal of cellular physiology}. United States: Wiley-Liss, 2012, roč.~227, č.~5, s.~1838-1850. ISSN~0021-9541. Dostupné z: https://dx.doi.org/10.1002/jcp.22912.

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