Characterization of PVL-phages induced from community-acquired
Staphylococcus aureus strains

a 2011

Characterization of PVL-phages induced from community-acquired Staphylococcus aureus strains

RÁJOVÁ, Jana, Roman PANTŮČEK, Ondrej ŠEDO, Petr PETRÁŠ, Ivana MACHOVÁ et. al.

Základní údaje

Originální název

Characterization of PVL-phages induced from community-acquired Staphylococcus aureus strains

Autoři

RÁJOVÁ, Jana, Roman PANTŮČEK, Ondrej ŠEDO, Petr PETRÁŠ, Ivana MACHOVÁ, Vladislava RŮŽIČKOVÁ, Zbyněk ZDRÁHAL a Jiří DOŠKAŘ

Vydání

4th Congress of European Microbiologists FEMS 2011, Geneva, Switzerland, 2011

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

Genetika a molekulární biologie

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizační jednotka

Přírodovědecká fakulta

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 10. 2011 10:52, prof. RNDr. Roman Pantůček, Ph.D.

Anotace

V originále

Temperate bacteriophages are important mediators of horizontal gene transfer of various virulence factors such as Panton-Valentine leukocidin (PVL) associated with community-acquired S. aureus strains. By spreading genes for PVL, the phages participate on the evolution of pathogenic bacteria. The goal of the study was to characterize the PVL phages occurring in Czech community-acquired MSSA and MRSA strains. According to the multiplex PCRs profiles we described four distinct groups between Czech PVL phages. One group is similar to phiSa2usa phage; two are relative to currently sequenced PVL-phages and the fourth represents new variants of PVL phages. Based on MALDI-MS profiles we observed different impact of phages on lysogenized strains. The results indicate parallel evolution of PVL phages and their horizontal transfer between various S. aureus clones. Further investigation will be performed to assed the impact of PVL phages in detail.

Návaznosti

GA310/09/0459, projekt VaV

Název: Úloha bakteriofágů v horizontálním přenosu genů virulence a rezistence u Staphylococcus aureus

Investor: Grantová agentura ČR, Úloha bakteriofágů v horizontálním přenosu genů virulence a rezistence u Staphylococcus aureus

MSM0021622415, záměr

Název: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární podstata buněčných a tkáňových regulací

Citovat

RÁJOVÁ, Jana, Roman PANTŮČEK, Ondrej ŠEDO, Petr PETRÁŠ, Ivana MACHOVÁ, Vladislava RŮŽIČKOVÁ, Zbyněk ZDRÁHAL a Jiří DOŠKAŘ. Characterization of PVL-phages induced from community-acquired Staphylococcus aureus strains. In 4th Congress of European Microbiologists FEMS 2011, Geneva, Switzerland. 2011.

@proceedings{953377,
   author = {Rájová, Jana and Pantůček, Roman and Šedo, Ondrej and Petráš, Petr and Machová, Ivana and Růžičková, Vladislava and Zdráhal, Zbyněk and Doškař, Jiří},
   booktitle = {4th Congress of European Microbiologists FEMS 2011, Geneva, Switzerland},
   language = {eng},
   title = {Characterization of PVL-phages induced from community-acquired Staphylococcus aureus strains},
   url = {http://www2.kenes.com/fems2011/Pages/Home.aspx},
   year = {2011}
}

TY  - CONF
ID  - 953377
AU  - Rájová, Jana - Pantůček, Roman - Šedo, Ondrej - Petráš, Petr - Machová, Ivana - Růžičková, Vladislava - Zdráhal, Zbyněk - Doškař, Jiří
PY  - 2011
TI  - Characterization of PVL-phages induced from community-acquired Staphylococcus aureus strains
UR  - http://www2.kenes.com/fems2011/Pages/Home.aspx
N2  - Temperate bacteriophages are important mediators of horizontal gene transfer of various virulence factors such as Panton-Valentine leukocidin (PVL) associated with community-acquired S. aureus strains. By spreading genes for PVL, the phages participate on the evolution of pathogenic bacteria. The goal of the study was to characterize the PVL phages occurring in Czech community-acquired MSSA and MRSA strains. According to the multiplex PCRs profiles we described four distinct groups between Czech PVL phages. One group is similar to phiSa2usa phage; two are relative to currently sequenced PVL-phages and the fourth represents new variants of PVL phages. Based on MALDI-MS profiles we observed different impact of phages on lysogenized strains. The results indicate parallel evolution of PVL phages and their horizontal transfer between various S. aureus clones. Further investigation will be performed to assed the impact of PVL phages in detail.
ER  -

RÁJOVÁ, Jana, Roman PANTŮČEK, Ondrej ŠEDO, Petr PETRÁŠ, Ivana MACHOVÁ, Vladislava RŮŽIČKOVÁ, Zbyněk ZDRÁHAL a Jiří DOŠKAŘ. Characterization of PVL-phages induced from community-acquired Staphylococcus aureus strains. In \textit{4th Congress of European Microbiologists FEMS 2011, Geneva, Switzerland}. 2011.

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