Aspergillus fumigatus lectin – a new procedure for studying
highly complex	interactions of multivalent lectins with their
ligands

a 2011

Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands

KOMÁREK, Jan, Josef HOUSER, Nikola KOSTLÁNOVÁ, Marie POKORNÁ, Anne IMBERTY et. al.

Základní údaje

Originální název

Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands

Autoři

KOMÁREK, Jan (203 Česká republika, domácí), Josef HOUSER (203 Česká republika, domácí), Nikola KOSTLÁNOVÁ (203 Česká republika, domácí), Marie POKORNÁ (203 Česká republika, domácí), Anne IMBERTY (250 Francie) a Michaela WIMMEROVÁ (203 Česká republika, garant, domácí)

Vydání

YoungChem 2011, 2011

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10600 1.6 Biological sciences

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/11:00050064

Organizační jednotka

Přírodovědecká fakulta

ISBN

978-83-61037-28-6

Klíčová slova česky

lektiny; Aspergillus fumigatus

Klíčová slova anglicky

lectins; Aspergillus fumigatus

Příznaky

Mezinárodní význam

Změněno: 13. 1. 2012 10:03, prof. RNDr. Michaela Wimmerová, Ph.D.

Anotace

V originále

Lectins are proteins or glycoproteins of non-immune origin which recognize and bind reversibly to diverse sugar structures. They are involved in recognition events in a variety of physiological and pathological processes. One of the most interesting biological function of these sugar-specific proteins is their involvement in host-pathogen interactions. Wide range of pathogenic bacteria and viruses use their surface lectins (called adhesins) for recognition and adhesion to host tissues – in the the crucial step for initiation of infection. Inhibition of these lectins by suitable carbohydrates or their analogs might prevent attachment of pathogens to host cells and prevent the disease outbreak. Aspergillus fumigatus is an ubiquitous saprophytic mold and opportunistic pathogen responsible for severe infections in immuno-compromised individuals. The project is focused on a detailed characterization of L-fucose specific lectin AFL from A. fumigatus.

Návaznosti

GA303/09/1168, projekt VaV

Název: Lektiny z lidských patogenů - struktura, funkce, inženýrství

Investor: Grantová agentura ČR, Lektidy z lidských patogenů - struktura, funkce, inženýrství

MSM0021622413, záměr

Název: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Proteiny v metabolismu a při interakci organismů s prostředím

Citovat

KOMÁREK, Jan, Josef HOUSER, Nikola KOSTLÁNOVÁ, Marie POKORNÁ, Anne IMBERTY a Michaela WIMMEROVÁ. Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands. In YoungChem 2011. 2011. ISBN 978-83-61037-28-6.

@proceedings{953482,
   author = {Komárek, Jan and Houser, Josef and Kostlánová, Nikola and Pokorná, Marie and Imberty, Anne and Wimmerová, Michaela},
   booktitle = {YoungChem 2011},
   keywords = {lectins; Aspergillus fumigatus},
   language = {eng},
   isbn = {978-83-61037-28-6},
   title = {Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands},
   year = {2011}
}

TY  - CONF
ID  - 953482
AU  - Komárek, Jan - Houser, Josef - Kostlánová, Nikola - Pokorná, Marie - Imberty, Anne - Wimmerová, Michaela
PY  - 2011
TI  - Aspergillus fumigatus lectin – a new procedure for studying highly complex interactions of multivalent lectins with their ligands
SN  - 9788361037286
KW  - lectins
KW  - Aspergillus fumigatus
N2  - Lectins are proteins or glycoproteins of non-immune origin which recognize and bind reversibly to diverse sugar structures. They are involved in recognition events in a variety of physiological and pathological processes. One of the most interesting biological function of these sugar-specific proteins is their involvement in host-pathogen interactions. Wide range of pathogenic bacteria and viruses use their surface lectins (called adhesins) for recognition and adhesion to host tissues – in the the crucial step for initiation of infection. Inhibition of these lectins by suitable carbohydrates or their analogs might prevent attachment of pathogens to host cells and prevent the disease outbreak. Aspergillus fumigatus is an ubiquitous saprophytic mold and opportunistic pathogen responsible for severe infections in immuno-compromised individuals. The project is focused on a detailed characterization of L-fucose specific lectin AFL from A. fumigatus.
ER  -

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