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@proceedings{954058,
author = {Paulová, Hana and Stračina, Tibor and Nováková, Marie and Táborská, Eva},
booktitle = {11th International Nutrition and Diagnostics Conference INDC 2011},
keywords = {isolated heart; guinea pig; hydroxyl radical; CK; LDH},
language = {eng},
isbn = {978-80-7395-378-2},
title = {In vivo determination of hydroxyl radicals in isolated guinea pig hearts during ischemia and reperfusion},
year = {2011}
}
TY - CONF
ID - 954058
AU - Paulová, Hana - Stračina, Tibor - Nováková, Marie - Táborská, Eva
PY - 2011
TI - In vivo determination of hydroxyl radicals in isolated guinea pig hearts during ischemia and reperfusion
SN - 9788073953782
KW - isolated heart
KW - guinea pig
KW - hydroxyl radical
KW - CK
KW - LDH
N2 - Myocardial ischemia-reperfusion injury is linked with production of oxygen free radicals. We evaluated the production of hydroxyl radical in isolated guinea pig hearts during ischemia and reperfusion. To investigate the other parameters of myocardial injury, we measured the creatine kinase, lactate dehydrogenase and lactate in collected effluents during both ischemia and reperfusion periods. The increased levels of CK, LDH and lactate and the comparison of these parameters with production of hydroxyl radicals shows that the hydroxyl radicals generation play important role in ischemia-reperfusion injury.
ER -
PAULOVÁ, Hana, Tibor STRAČINA, Marie NOVÁKOVÁ a Eva TÁBORSKÁ. In vivo determination of hydroxyl radicals in isolated guinea pig hearts during ischemia and reperfusion. In \textit{11th International Nutrition and Diagnostics Conference INDC 2011}. 2011. ISBN~978-80-7395-378-2.
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