Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients

ŠVÁCHOVÁ, Hana, Luděk POUR, Jiří ŠÁNA, Lucie ŘÍHOVÁ, Karthick Raja MUTHU RAJA and Roman HÁJEK. Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients. Leukemia Research. 2011, vol. 35, No 8, p. 1008-1013. ISSN 0145-2126. Available from: https://dx.doi.org/10.1016/j.leukres.2011.03.001.

Basic information

• Original name: Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients
• Authors: ŠVÁCHOVÁ, Hana (203 Czech Republic, guarantor, belonging to the institution), Luděk POUR (203 Czech Republic, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Lucie ŘÍHOVÁ (203 Czech Republic, belonging to the institution), Karthick Raja MUTHU RAJA (356 India, belonging to the institution) and Roman HÁJEK (203 Czech Republic, belonging to the institution).
• Edition: Leukemia Research, 2011, 0145-2126.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.923
• RIV identification code: RIV/00216224:14110/11:00050101
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.leukres.2011.03.001
• UT WoS: 000292735300007
• Keywords in English: Nestin; Plasma cells; Multiple myeloma; Myeloma stem cells; Flow cytometry
• Tags: International impact

Abstract

Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma.

Links

• GAP304/10/1395, research and development project: Name: Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií

Investor: Czech Science Foundation

• LC06027, research and development project: Name: Univerzitní výzkumné centrum - Česká myelomová skupina (Acronym: LC MGUS)

Investor: Ministry of Education, Youth and Sports of the CR, University Research Centre - Czech Myeloma Group

• MSM0021622434, plan (intention): Name: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií

Investor: Ministry of Education, Youth and Sports of the CR, From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies