Withdrawal related adverse effects of antipsychotic medication
in a patient with first-episode schizophrenia

J 2011

Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia

BARTEČEK, Richard, Tomáš KAŠPÁREK a Eva ČEŠKOVÁ

Základní údaje

Originální název

Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia

Název česky

Zmínění nežádoucích účinků antipsychotické medikace u pacientů s první epizodou schizofrenie

Autoři

BARTEČEK, Richard (203 Česká republika, garant, domácí), Tomáš KAŠPÁREK (203 Česká republika, domácí) a Eva ČEŠKOVÁ (203 Česká republika, domácí)

Vydání

Central European Journal of Medicine, Warsaw (Poland), Versita, 2011, 1895-1058

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.312

Kód RIV

RIV/00216224:14110/11:00053792

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2478/s11536-011-0055-8

UT WoS

000293708800022

Klíčová slova česky

schizofrenie; antipsychotika; zmírnění nežádoucích účinků

Klíčová slova anglicky

schizophrenia; antipsychotics; withdrawal related adverse effects

Příznaky

Mezinárodní význam

Změněno: 2. 2. 2012 16:12, Mgr. Michal Petr

Anotace

V originále

Withdrawal-emergent adverse effects of antipsychotics are an infrequently identified condition which can appear during antipsychotic dose reduction and medication change. In this paper, we present the case of severe extrapyramidal symptoms after a dose reduction of risperidone is presented. A patient, 23 years of age, was admitted to a health care facility due to an unexpected change in his behavior, with paranoid delusions, incoherent thinking, and significant anxiety. An initial risperidone treatment was soon changed to zuclopenhixol. Subsequently, severe extrapyramidal symptoms appeared, after which the medication was switched back to resperidone. Following this treatment, the patient left the health care facility and stopped the medication of his own volition. Psychotic symptoms and massive extrapyramidal symptoms again occurred. These symptoms subsided only slowly during a subsequent treatment with olanzapine. The development of adverse neurological effects together with a worsening of productive psychotic symptomatology may be explained by withdrawal of antipsychotic medication. These symptoms are often attributed to new medications, which are prematurely discontinued after the appearance of an adverse effect, but which are potentially beneficial to a patient, provided that enough time for a spontaneous subsidence of withdrawal-emergent effects is given. Any change in antipsychotic treatment should be carefully considered and thoroughly planned.

Citovat

BARTEČEK, Richard, Tomáš KAŠPÁREK a Eva ČEŠKOVÁ. Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia. Central European Journal of Medicine. Warsaw (Poland): Versita, 2011, roč. 6, č. 5, s. 662-664. ISSN 1895-1058. Dostupné z: https://dx.doi.org/10.2478/s11536-011-0055-8.

@article{956232,
   author = {Barteček, Richard and Kašpárek, Tomáš and Češková, Eva},
   article_location = {Warsaw (Poland)},
   article_number = {5},
   doi = {http://dx.doi.org/10.2478/s11536-011-0055-8},
   keywords = {schizophrenia; antipsychotics; withdrawal related adverse effects},
   language = {eng},
   issn = {1895-1058},
   journal = {Central European Journal of Medicine},
   title = {Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia},
   volume = {6},
   year = {2011}
}

TY  - JOUR
ID  - 956232
AU  - Barteček, Richard - Kašpárek, Tomáš - Češková, Eva
PY  - 2011
TI  - Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia
JF  - Central European Journal of Medicine
VL  - 6
IS  - 5
SP  - 662-664
EP  - 662-664
PB  - Versita
SN  - 18951058
KW  - schizophrenia
KW  - antipsychotics
KW  - withdrawal related adverse effects
N2  - Withdrawal-emergent adverse effects of antipsychotics are an infrequently identified condition which can appear during antipsychotic dose reduction and medication change. In this paper, we present the case of severe extrapyramidal symptoms after a dose reduction of risperidone is presented. A patient, 23 years of age, was admitted to a health care facility due to an unexpected change in his behavior, with paranoid delusions, incoherent thinking, and significant anxiety. An initial risperidone treatment was soon changed to zuclopenhixol. Subsequently, severe extrapyramidal symptoms appeared, after which the medication was switched back to resperidone. Following this treatment, the patient left the health care facility and stopped the medication of his own volition. Psychotic symptoms and massive extrapyramidal symptoms again occurred. These symptoms subsided only slowly during a subsequent treatment with olanzapine. The development of adverse neurological effects together with a worsening of productive psychotic symptomatology may be explained by withdrawal of antipsychotic medication. These symptoms are often attributed to new medications, which are prematurely discontinued after the appearance of an adverse effect, but which are potentially beneficial to a patient, provided that enough time for a spontaneous subsidence of withdrawal-emergent effects is given. Any change in antipsychotic treatment should be carefully considered and thoroughly planned.
ER  -

BARTEČEK, Richard, Tomáš KAŠPÁREK a Eva ČEŠKOVÁ. Withdrawal related adverse effects of antipsychotic medication in a patient with first-episode schizophrenia. \textit{Central European Journal of Medicine}. Warsaw (Poland): Versita, 2011, roč.~6, č.~5, s.~662-664. ISSN~1895-1058. Dostupné z: https://dx.doi.org/10.2478/s11536-011-0055-8.

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