Další formáty:
BibTeX
LaTeX
RIS
@article{957235,
author = {Bittner, Michal and Macíková, Petra and Giesy, John P. and Hilscherová, Klára},
article_location = {OXFORD, ENGLAND},
article_number = {5},
doi = {http://dx.doi.org/10.1016/j.envint.2011.03.016},
keywords = {Humic substances; AhR; Mixture; Interaction; H4IIE-luc; Organic pollutants},
language = {eng},
issn = {0160-4120},
journal = {Environment International},
title = {Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter},
volume = {37},
year = {2011}
}
TY - JOUR
ID - 957235
AU - Bittner, Michal - Macíková, Petra - Giesy, John P. - Hilscherová, Klára
PY - 2011
TI - Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter
JF - Environment International
VL - 37
IS - 5
SP - 960-964
EP - 960-964
PB - PERGAMON-ELSEVIER
SN - 01604120
KW - Humic substances
KW - AhR
KW - Mixture
KW - Interaction
KW - H4IIE-luc
KW - Organic pollutants
N2 - In vitro effects of binary mixtures of various DOM (mainly HS) with various HOCs on AhR-mediated responses were studied by use of H4IIE-luc cells. 6 out of 12 DOM activated the AhR even at environmentally relevant concentrations (17 mg L(-1)). In simultaneous exposures of H4IIE-luc cells to DOM and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of POPs, a mixture of PAHs, and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs. No significant decrease of effects due to sorption of HOCs to DOM was observed, even in subsequent experiments when HOCs + DOM mixtures were preincubated for six days before exposure to H4IIE-luc. Thus, DOM does not seem to protect organisms against AhR-mediated toxic effects of HOCs (as predicted due to sorption of HOCs on DOM), but it can enhance their potency for AhR-mediated effects in some situations.
ER -
BITTNER, Michal, Petra MACÍKOVÁ, John P. GIESY a Klára HILSCHEROVÁ. Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter. \textit{Environment International}. OXFORD, ENGLAND: PERGAMON-ELSEVIER, 2011, roč.~37, č.~5, s.~960-964. ISSN~0160-4120. Dostupné z: https://dx.doi.org/10.1016/j.envint.2011.03.016.
|
