Enhancement of AhR-mediated activity of selected pollutants and
their mixtures after interaction with dissolved organic matter

J 2011

Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter

BITTNER, Michal, Petra MACÍKOVÁ, John P. GIESY a Klára HILSCHEROVÁ

Základní údaje

Originální název

Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter

Autoři

BITTNER, Michal (203 Česká republika, domácí), Petra MACÍKOVÁ (203 Česká republika, domácí), John P. GIESY (124 Kanada) a Klára HILSCHEROVÁ (203 Česká republika, garant, domácí)

Vydání

Environment International, OXFORD, ENGLAND, PERGAMON-ELSEVIER, 2011, 0160-4120

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.297

Kód RIV

RIV/00216224:14310/11:00050132

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.envint.2011.03.016

UT WoS

000292012100017

Klíčová slova anglicky

Humic substances; AhR; Mixture; Interaction; H4IIE-luc; Organic pollutants

Štítky

AKR, rivok

Změněno: 10. 7. 2017 13:45, RNDr. Mgr. Michal Bittner, Ph.D.

Anotace

V originále

In vitro effects of binary mixtures of various DOM (mainly HS) with various HOCs on AhR-mediated responses were studied by use of H4IIE-luc cells. 6 out of 12 DOM activated the AhR even at environmentally relevant concentrations (17 mg L(-1)). In simultaneous exposures of H4IIE-luc cells to DOM and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of POPs, a mixture of PAHs, and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs. No significant decrease of effects due to sorption of HOCs to DOM was observed, even in subsequent experiments when HOCs + DOM mixtures were preincubated for six days before exposure to H4IIE-luc. Thus, DOM does not seem to protect organisms against AhR-mediated toxic effects of HOCs (as predicted due to sorption of HOCs on DOM), but it can enhance their potency for AhR-mediated effects in some situations.

Návaznosti

ED0001/01/01, projekt VaV

Název: CETOCOEN

GP525/08/P464, projekt VaV

Název: Interakce huminových látek a UV-VIS záření s dioxinově aktivními environmentálními polutanty

Investor: Grantová agentura ČR, Interakce huminových látek a UV-VIS záření s dioxinově aktivními environmentálními polutanty

MSM0021622412, záměr

Název: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Akronym: INCHEMBIOL)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální , regionální a lokální úrovni

Citovat

BITTNER, Michal, Petra MACÍKOVÁ, John P. GIESY a Klára HILSCHEROVÁ. Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter. Environment International. OXFORD, ENGLAND: PERGAMON-ELSEVIER, 2011, roč. 37, č. 5, s. 960-964. ISSN 0160-4120. Dostupné z: https://dx.doi.org/10.1016/j.envint.2011.03.016.

@article{957235,
   author = {Bittner, Michal and Macíková, Petra and Giesy, John P. and Hilscherová, Klára},
   article_location = {OXFORD, ENGLAND},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.envint.2011.03.016},
   keywords = {Humic substances; AhR; Mixture; Interaction; H4IIE-luc; Organic pollutants},
   language = {eng},
   issn = {0160-4120},
   journal = {Environment International},
   title = {Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter},
   volume = {37},
   year = {2011}
}

TY  - JOUR
ID  - 957235
AU  - Bittner, Michal - Macíková, Petra - Giesy, John P. - Hilscherová, Klára
PY  - 2011
TI  - Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter
JF  - Environment International
VL  - 37
IS  - 5
SP  - 960-964
EP  - 960-964
PB  - PERGAMON-ELSEVIER
SN  - 01604120
KW  - Humic substances
KW  - AhR
KW  - Mixture
KW  - Interaction
KW  - H4IIE-luc
KW  - Organic pollutants
N2  - In vitro effects of binary mixtures of various DOM (mainly HS) with various HOCs on AhR-mediated responses were studied by use of H4IIE-luc cells. 6 out of 12 DOM activated the AhR even at environmentally relevant concentrations (17 mg L(-1)). In simultaneous exposures of H4IIE-luc cells to DOM and each of the model compounds, 2,3,7,8-TCDD, PCB126, PCB169, benzo[a]pyrene, benzo[a]anthracene, dibenz[a,h]anthracene, fluoranthene, a mixture of POPs, a mixture of PAHs, and a mixture of all HOCs, either significant additive or facilitative effects were observed when compared to activities of single HOCs. No significant decrease of effects due to sorption of HOCs to DOM was observed, even in subsequent experiments when HOCs + DOM mixtures were preincubated for six days before exposure to H4IIE-luc. Thus, DOM does not seem to protect organisms against AhR-mediated toxic effects of HOCs (as predicted due to sorption of HOCs on DOM), but it can enhance their potency for AhR-mediated effects in some situations.
ER  -

BITTNER, Michal, Petra MACÍKOVÁ, John P. GIESY a Klára HILSCHEROVÁ. Enhancement of AhR-mediated activity of selected pollutants and their mixtures after interaction with dissolved organic matter. \textit{Environment International}. OXFORD, ENGLAND: PERGAMON-ELSEVIER, 2011, roč.~37, č.~5, s.~960-964. ISSN~0160-4120. Dostupné z: https://dx.doi.org/10.1016/j.envint.2011.03.016.

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