BOUCHAL, Pavel, Jiří JARKOVSKÝ, Kristýna HRAZDILOVÁ, Monika DVOŘÁKOVÁ, Iva STRUHÁROVÁ, Lenka HERNYCHOVÁ, Jiří DAMBORSKÝ, Petr SOVA a Bořivoj VOJTĚŠEK. The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo. Proteome Science. BioMed Central, 2011, roč. 9, č. 68, s. "nestránkováno", 9 s. ISSN 1477-5956. Dostupné z: https://dx.doi.org/10.1186/1477-5956-9-68. |
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@article{958893, author = {Bouchal, Pavel and Jarkovský, Jiří and Hrazdilová, Kristýna and Dvořáková, Monika and Struhárová, Iva and Hernychová, Lenka and Damborský, Jiří and Sova, Petr and Vojtěšek, Bořivoj}, article_number = {68}, doi = {http://dx.doi.org/10.1186/1477-5956-9-68}, keywords = {(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum (IV) (LA-12); plasma retinol-binding protein 4; RBP4; cisplatin; adamantylamine; proteomics}, language = {eng}, issn = {1477-5956}, journal = {Proteome Science}, title = {The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo}, url = {http://www.proteomesci.com/content/9/1/68}, volume = {9}, year = {2011} }
TY - JOUR ID - 958893 AU - Bouchal, Pavel - Jarkovský, Jiří - Hrazdilová, Kristýna - Dvořáková, Monika - Struhárová, Iva - Hernychová, Lenka - Damborský, Jiří - Sova, Petr - Vojtěšek, Bořivoj PY - 2011 TI - The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo JF - Proteome Science VL - 9 IS - 68 SP - "nestránkováno" EP - "nestránkováno" PB - BioMed Central SN - 14775956 KW - (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum (IV) (LA-12) KW - plasma retinol-binding protein 4 KW - RBP4 KW - cisplatin KW - adamantylamine KW - proteomics UR - http://www.proteomesci.com/content/9/1/68 L2 - http://www.proteomesci.com/content/9/1/68 N2 - Background: The initial pharmacokinetic study of a new anticancer agent (OC-6-43)-bis(acetato)(1-adamantylamine) amminedichloroplatinum (IV) (LA-12) was complemented by proteomic screening of rat plasma. The objective of the study was to identify new LA-12 target proteins that serve as markers of LA-12 treatment, response and therapy monitoring. Methods: Proteomic profiles were measured by surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF MS) in 72 samples of rat plasma randomized according to LA-12 dose and time from administration. Correlation of 92 peak clusters with platinum concentration was evaluated using Spearman correlation analysis. Results: We identified Retinol-binding protein 4 (RBP4) whose level correlated with LA-12 level in treated rats. Similar results were observed in randomly selected patients involved in Phase I clinical trials. Conclusions: RBP4 induction is in agreement with known RBP4 regulation by amantadine and cisplatin. ER -
BOUCHAL, Pavel, Jiří JARKOVSKÝ, Kristýna HRAZDILOVÁ, Monika DVOŘÁKOVÁ, Iva STRUHÁROVÁ, Lenka HERNYCHOVÁ, Jiří DAMBORSKÝ, Petr SOVA a Bořivoj VOJTĚŠEK. The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo. \textit{Proteome Science}. BioMed Central, 2011, roč.~9, č.~68, s.~''nestránkováno'', 9 s. ISSN~1477-5956. Dostupné z: https://dx.doi.org/10.1186/1477-5956-9-68.
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