| HRUBÁ, Eva, Jan VONDRÁČEK, Helena LÍBALOVÁ, Jan TOPINKA, Vítězslav BRYJA, Karel SOUČEK and Miroslav MACHALA. Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. TOXICOLOGY LETTERS. Ireland: ELSEVIER IRELAND LTD, 2011, vol. 206, No 2, p. 178-188. ISSN 0378-4274. Available from: https://dx.doi.org/10.1016/j.toxlet.2011.07.011. |
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@article{961006,
author = {Hrubá, Eva and Vondráček, Jan and Líbalová, Helena and Topinka, Jan and Bryja, Vítězslav and Souček, Karel and Machala, Miroslav},
article_location = {Ireland},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.toxlet.2011.07.011},
keywords = {LNCaP cells; benzo[a]pyrene; 2-3-7-8-tetrachlorodibenzo-p-dioxin; cell cycle; WNT5A; E2F1},
language = {eng},
issn = {0378-4274},
journal = {TOXICOLOGY LETTERS},
title = {Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands},
volume = {206},
year = {2011}
}
TY - JOUR
ID - 961006
AU - Hrubá, Eva - Vondráček, Jan - Líbalová, Helena - Topinka, Jan - Bryja, Vítězslav - Souček, Karel - Machala, Miroslav
PY - 2011
TI - Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands
JF - TOXICOLOGY LETTERS
VL - 206
IS - 2
SP - 178-188
EP - 178-188
PB - ELSEVIER IRELAND LTD
SN - 03784274
KW - LNCaP cells
KW - benzo[a]pyrene
KW - 2-3-7-8-tetrachlorodibenzo-p-dioxin
KW - cell cycle
KW - WNT5A
KW - E2F1
N2 - Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. In order to evaluate the complex relationship between the genotoxicity and the AhR-mediated activity of PAHs in prostate cells, we explored global changes in gene expression in LNCaP cells by microarray analysis. We identified 112 genes that were differentially expressed in cells treated for 24 h with BaP, TCDD or both compounds. Our data indicated that the impacts of BaP and TCDD on transcriptome of LNCaP cells significantly overlap, since over 64 % of significantly up-regulated genes and 47% of downregulated genes were similarly affected by both AhR ligands. The AhR ligand-induced Wnt5a upregulation, together with other observed alterations of gene expression, may further contribute to enhanced cell plasticity of prostate carcinoma cells.
ER -
HRUBÁ, Eva, Jan VONDRÁČEK, Helena LÍBALOVÁ, Jan TOPINKA, Vítězslav BRYJA, Karel SOUČEK and Miroslav MACHALA. Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands. \textit{TOXICOLOGY LETTERS}. Ireland: ELSEVIER IRELAND LTD, 2011, vol.~206, No~2, p.~178-188. ISSN~0378-4274. Available from: https://dx.doi.org/10.1016/j.toxlet.2011.07.011.
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