Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms

LUBAL, Přemysl, MPC CAMPELLO, Radek ŠEVČÍK, Jakub VANĚK, Romana ŠEVČÍKOVÁ, Petr HERMANN, Isabel SANTOS and Manuel MARTINEZ. Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms. In 11 ISABC - International Symposium on Applied Bioinorganic Chemistry. 2011.

Basic information

• Original name: Solution Study of Metal Complexes with Macrocyclic Ligands having Carboxylate and Phosphonate Pendant Arms
• Authors: LUBAL, Přemysl (203 Czech Republic, guarantor, belonging to the institution), MPC CAMPELLO (620 Portugal), Radek ŠEVČÍK (203 Czech Republic, belonging to the institution), Jakub VANĚK (203 Czech Republic, belonging to the institution), Romana ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution), Petr HERMANN (203 Czech Republic), Isabel SANTOS (620 Portugal) and Manuel MARTINEZ (724 Spain).
• Edition: 11 ISABC - International Symposium on Applied Bioinorganic Chemistry, 2011.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10402 Inorganic and nuclear chemistry
• Country of publisher: Spain
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14740/11:00054679
• Organization unit: Central European Institute of Technology
• Keywords in English: Macrocyclic Ligands; thermodynamics; kinetics; Ln(III) complexes; Cu(II) ion
• Tags: rivok

Abstract

Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1, 2] are presented. The substitution of acetate functional group(s) by phosphonate(s) has a definite impact on the kinetic inertness of the mentioned metal complexes and, therefore, this fact should be taken for possible in vivo application as BFC’s.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• LC06035, research and development project: Name: Centrum biofyzikální chemie, bioelektrochemie a bioanalýzy. Nové nástroje pro genomiku, proteomiku a biomedicínu.

Investor: Ministry of Education, Youth and Sports of the CR, Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine

• ME09065, research and development project: Name: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze

Investor: Ministry of Education, Youth and Sports of the CR, Research of new detection systems based on sensor arrays for application in speciation analysis, Research and Development Programme KONTAKT (ME)

• MUNI/A/0992/2009, interní kód MU: Name: Vývoj metodologie a instrumentace analytické chemie pro studium složení a vlastností přírodních a syntetických materiálů (Acronym: MIA)

Investor: Masaryk University, Category A